Electron paramagnetic resonance spectroscopy has been applied for the first time to study the bio-distribution of magnetoliposomes formed with magnetite nanoparticles (Fe 3 O 4 ) in tumors and organs of Lewis carcinoma-bearing mice in the absence and presence of an external magnetic field. The animals of the experimental group were subjected to an external magnetic field (0.6 T) in the tumor area after intravenous injection of magnetoliposomes at a dose of 7.56 Fe/kg. Analysis of the electron-spin resonance spectra of mouse organs and tissue samples showed that exposure to a magnetic field resulted in a two-fold increase in Fe 3 O 4 accumulation within the tumor ( p < 0.05) compared to the control; this makes it possible to recommend the obtained magnetoliposomes for use as a magnetically controlled carriers for targeted delivery of antitumor agents. A high concentration of superparamagnetic magnetite nanoparticles was detected in the liver in the absence and presence of an external magnetic field. The differences in the accumulation of Fe 3 O 4 in the lungs and liver in the presence of a magnetic field were statistically insignificant.

中文翻译：

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用电子顺磁共振光谱法评价磁脂质体在小鼠肿瘤和器官中的生物分布

电子顺磁共振波谱首次应用于研究在没有和存在外部磁场的情况下，由磁铁矿纳米颗粒 (Fe 3 O 4 ) 形成的磁脂质体在荷路易斯癌小鼠的肿瘤和器官中的生物分布。实验组动物以7.56 Fe/kg的剂量静脉注射磁脂质体后，在肿瘤区施加外磁场（0.6 T）。小鼠器官和组织样本的电子自旋共振光谱分析表明，与对照相比，暴露于磁场导致肿瘤内 Fe 3 O 4 积累增加两倍 (p < 0.05)；这使得推荐获得的磁脂质体作为磁控载体用于靶向递送抗肿瘤剂成为可能。在外部磁场不存在和存在的情况下，在肝脏中检测到高浓度的超顺磁性磁铁矿纳米颗粒。在存在磁场的情况下，Fe 3 O 4 在肺和肝中积累的差异在统计上是不显着的。