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Ligand Absorption on DNA Duplexes under the Influence of a Fluctuating Medium Changes the Output Signal of a DNA Biosensor
Biophysics Pub Date : 2020-10-19 , DOI: 10.1134/s0006350920040028
V. B. Arakelyan , A. P. Antonyan , M. A. Parsadanyan , M. A. Shahinyan , P. O. Vardevanyan

Ligand binding to DNA duplexes in a DNA biosensor was studied in conditions where the number of ligand molecules in the solution fluctuates under the influence of a fluctuating medium (external noise). A multiplicative stochastic differential equation was obtained for the case of low occupancy to describe the time-dependent change in the number of ligands absorbed on DNA duplexes. The average value and relaxation time of the output signal of a DNA biosensor were calculated as functions of ligand absorption on DNA duplexes in a fluctuating medium. Multiplicative noise was shown to decrease the average output signal of a DNA biosensor. Signal deterioration was found to have a threshold; i.e., the signal is not deteriorated at a certain ratio between the absorption parameters and the intensity of external noise. The relaxation time of the output signal of a DNA biosensor was shown to increase with the increasing intensity of external noise.



中文翻译:

DNA双链体上的配体吸收在波动介质的影响下改变了DNA生物传感器的输出信号

在溶液中配体分子的数量在波动介质(外部噪声)的影响下波动的条件下,研究了DNA生物传感器中配体与DNA双链体的结合。对于低占用率情况,获得了一个乘法随机微分方程,用于描述DNA双链体上吸收的配体数量随时间的变化。计算DNA生物传感器输出信号的平均值和弛豫时间,作为波动介质中DNA双链体上配体吸收的函数。结果表明,乘性噪声会降低DNA生物传感器的平均输出信号。发现信号恶化有阈值;即,信号在吸收参数和外部噪声的强度之间没有一定比例的恶化。

更新日期:2020-10-19
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