Abstract

A simple and efficient microwave-assisted protocol has been developed for the synthetic of a series of novel pyrazole–indanone hybrid analogs. The target compounds have been synthesized by the Claisen–Schmidt condensation of different 1,3-diphenyl-1H-pyrazole-4-carbaldehydes with 2,3-dihydro-1H-inden-1-one in the presence of potassium hydroxide. The compounds were characterized by IR, ¹H and ¹³C NMR, and mass spectra and were found to exhibit potent antimicrobial activity in vitro.

中文翻译：

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新型吡唑-茚满酮杂合体的微波辅助合成和抑菌活性

摘要

已经开发了一种简单有效的微波辅助方案，用于合成一系列新型的吡唑-茚满酮杂合类似物。在氢氧化钾的存在下，通过不同的1,3-二苯基-1 H-吡唑-4-甲醛与2，3-二氢-1 H-茚-1的Claisen-Schmidt缩合反应合成了目标化合物。通过IR，¹ H和¹³ C NMR和质谱对化合物进行表征，发现它们在体外显示出有效的抗菌活性。