Abstract

A new approach has been proposed to the synthesis of optically active 4H-3,1-benzoxazine derivatives based on α-amino acids. The target products have been obtained by reaction of o-(cyclopent-1-en-1-yl)aniline with N-Boc-protected amino acids, followed by removal of the protecting group and heterocyclization by the action of dry hydrogen chloride in methylene chloride.

中文翻译：

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邻-（1-环烯基）苯胺的分子内杂环化：III。基于α-氨基酸的光学活性4 H -3,1-苯并恶嗪的合成

摘要

已经提出了基于α-氨基酸合成旋光的4 H -3,1-苯并恶嗪衍生物的新方法。通过使邻-（环戊-1-烯-1-基）苯胺与N -Boc保护的氨基酸反应，然后除去保护基团并通过在二氯甲烷中的干燥氯化氢的作用进行杂环化，可以得到目标产物。氯化物。