Abstract

Reactions of 3-(furan-2-ylmethyl)-2-sulfanyidene-1,3-thiazolidin-4-one with aromatic and heterocyclic aldehydes afforded a series of previously unknown 5-[(het)arylmethylidene]-3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-ones. Treatment of 3-(furan-2-ylmethyl)-2-sulfanylidene-1,3-thiazolidin-4-one with thionyl chloride gave in a good yield 3,3′-bis(furan-2-ylmethyl)-2,2′-disulfanylidene-5,5′-bi-1,3-thiazolidinylidene-4,4′-dione which was reduced with zinc in acetic acid to 3,3′-bis(furan-2-ylmethyl)-2,2′-disulfanylidene-5,5′-bi-1,3-thiazolidine-4,4′-dione. The synthesized compounds were screened for antitumor activity.

中文翻译：

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3-（呋喃-2-基甲基）-2-亚磺酰基-1,3-噻唑烷酮-4-一的新的5-亚烷基衍生物的合成和抗肿瘤活性

摘要

3-（呋喃-2-基甲基）-2-亚磺酰基-1,3-噻唑烷丁-4-酮与芳族和杂环醛的反应提供了一系列先前未知的5-[（（杂）芳基亚甲基] -3-（呋喃- 2-基甲基）-2-亚磺酰基-1,3-噻唑烷酮-4。用亚硫酰氯处理3-（呋喃-2-基甲基）-2-亚磺酰基-1,3-噻唑烷丁-4-一，得到良好的收率3,3'-双（呋喃-2-基甲基）-2,2 '-二硫亚烷基-5,5'-bi-1,3-噻唑烷亚叉基-4,4'-二酮，在乙酸中被锌还原为3,3'-双（呋喃-2-基甲基）-2,2' -二亚磺酰基-5,5'-bi-1,3-噻唑烷-4,4'-二酮。筛选合成的化合物的抗肿瘤活性。