A major public health concern in Mexico is the natural contamination of groundwater with fluoride and arsenic. Therefore, this work aimed to evaluate the magnitude of human health risk after determining fluoride and arsenic concentrations in groundwater samples (n = 50) from the Metropolitan area of the city of San Luis Potosi, Mexico. Fluoride levels in water were determined via a potentiometric method using an ion-selective electrode. Arsenic concentrations in water samples were determined with an Atomic Absorption technique. Subsequently, a probabilistic health risk assessment was developed (Monte Carlo Analysis). Fluoride levels in water ranged from 0.20 to 3.50 mg/L. For arsenic, the mean level found in the assessed water samples was 15.5 ± 5.50 μg/L (range: 2.50–30.0 μg/L). In addition, when the probabilistic health risk assessment was completed, a mean HI (cumulative hazardous index) of higher than 1 was detected, indicating a high NCR (non-carcinogenic risk) for children and adults. According to the results found in this study, exposure protection campaigns are imperative in the Metropolitan area of the city of San Luis Potosí, Mexico, to successfully diminish exposure to arsenic and fluoride and, as a consequence, decrease the NCR in the population living in that region of Mexico.

墨西哥主要的公共卫生问题是地下水中的氟化物和砷自然污染。因此，这项工作旨在在确定地下水样品中的氟化物和砷浓度后评估人类健康风险的幅度（n = 50）来自墨西哥圣路易斯波托西市的都市区。使用离子选择电极通过电位法确定水中的氟化物含量。水样中的砷浓度通过原子吸收技术测定。随后，进行了概率健康风险评估（蒙特卡洛分析）。水中的氟化物含量范围为0.20至3.50 mg / L。对于砷，评估水样中的平均砷含量为15.5±5.50μg/ L（范围：2.50–30.0μg/ L）。此外，当概率健康风险评估完成时，平均HI（累积危险指数）大于1，表明儿童和成人的NCR（非致癌风险）较高。根据这项研究的结果，