The dynamic coordination of processes controlling the quality of the mitochondrial network is crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial proteolytic system, dynamics (fusion/fission), and mitophagy induce pathways that affect muscle mass and performance. When muscle mass is lost, the risk of disease onset and premature death is dramatically increased. For instance, poor quality of muscles correlates with the onset progression of several age-related disorders such as diabetes, obesity, cancer, and aging sarcopenia. To date, there are no drug therapies to reverse muscle loss, and exercise remains the best approach to improve mitochondrial health and to slow atrophy in several diseases. This review will describe the principal mechanisms that control mitochondrial quality and the pathways that link mitochondrial dysfunction to muscle mass regulation.

控制线粒体网络质量的过程的动态协调对于维持骨骼肌线粒体的功能至关重要。线粒体蛋白水解系统，动力学（融合/裂变）和线粒体的变化会诱导影响肌肉质量和性能的途径。当肌肉质量下降时，疾病发作和过早死亡的风险会大大增加。例如，不良的肌肉质量与一些与年龄相关的疾病（例如糖尿病，肥胖，癌症和衰老的肌肉减少症）的发作有关。迄今为止，尚无药物疗法可逆转肌肉损失，运动仍然是改善线粒体健康和减缓某些疾病中萎缩的最佳方法。