Artificial imine reductases: developments and future directions,RSC Chemical Biology

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Artificial imine reductases: developments and future directions
RSC Chemical Biology ( IF 4.2 ) Pub Date : 2020-10-16 , DOI: 10.1039/d0cb00113a
Rosalind L Booth ₁ , Gideon Grogan ₂ , Keith S Wilson ₂ , Anne-Kathrin Duhme-Klair ₁

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Biocatalytic imine reduction has been a topic of intense research by the artificial metalloenzyme community in recent years. Artificial constructs, together with natural enzymes, have been engineered to produce chiral amines with high enantioselectivity. This review examines the design of the main classes of artificial imine reductases reported thus far and summarises approaches to enhancing their catalytic performance using complementary methods. Examples of utilising these biocatalysts in vivo or in multi-enzyme cascades have demonstrated the potential that artIREDs can offer, however, at this time their use in biocatalysis remains limited. This review explores the current scope of artIREDs and the strategies used for catalyst improvement, and examines the potential for artIREDs in the future.

中文翻译：

人工亚胺还原酶：发展和未来方向

近年来，生物催化亚胺还原一直是人工金属酶界研究的热点。人工构建体与天然酶一起被设计用于生产具有高对映选择性的手性胺。本综述研究了迄今为止报道的主要类型的人工亚胺还原酶的设计，并总结了使用补充方法增强其催化性能的方法。在体内或多酶级联中使用这些生物催化剂的例子已经证明了 artIRED 可以提供的潜力，然而，目前它们在生物催化中的应用仍然有限。本综述探讨了 artIRED 的当前范围和用于催化剂改进的策略，并探讨了 artIRED 未来的潜力。

更新日期：2020-11-03

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