Highly efficient biocatalytic cascade for the diversity-oriented synthesis of complex blood group Sda antigens,Green Chemistry

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Highly efficient biocatalytic cascade for the diversity-oriented synthesis of complex blood group Sda antigens
Green Chemistry ( IF 9.3 ) Pub Date : 2020-10-17 , DOI: 10.1039/d0gc02971h
Kan Zhong _{1,

2,

3,

4,

5} , Jinfeng Ye _{1,

2,

3,

4,

5} , Xinhao Zhu _{1,

2,

3,

4,

5} , Hongzhi Cao _{1,

2,

3,

4,

5} , Chang-Cheng Liu _{1,

2,

3,

4,

5}

Affiliation

Sd^a antigens are a family of widely distributed histo-blood group antigens sharing the Siaα2,3(GalNAcβ1,4)Gal trisaccharide determinant. Despite their significant biological importance, the synthesis of these complex carbohydrate antigens is challenging. Herein, we report a highly efficient and green synthesis of diverse Sd^a antigens with different underlying structures and sialic acid forms utilizing 6 multienzyme cascade reaction systems. The multienzyme cascade approach combines sugar nucleotide donor generation enzymes and glycosyltransferases, providing an efficient and convenient approach for the rapid assembly of complex glycans from simple monosaccharide building blocks.

中文翻译：

用于复杂血型Sda抗原多样性导向合成的高效生物催化级联

Sd ^a抗原是共享Siaα2,3（GalNAcβ1,4）Gal三糖决定簇的广泛分布的组织血型抗原家族。尽管它们具有重要的生物学重要性，但是这些复杂碳水化合物抗原的合成仍具有挑战性。在此，我们报告了利用6种多酶级联反应系统高效，绿色合成具有不同基础结构和唾液酸形式的多种Sd ^a抗原的方法。多酶级联方法结合了糖核苷酸供体产生酶和糖基转移酶，为从简单的单糖结构单元快速组装复杂的聚糖提供了一种有效而方便的方法。

更新日期：2020-11-03

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