Oxyresveratrol, a polyphenolic compound, has been reported as having antioxidant and anti-inflammatory effects. This study determined the neuroprotective effects of oxyresveratrol, extracted from the heartwood of Artocarpus lakoocha Roxburgh (Moraceae), on parkinsonism induced by rotenone. Male Wistar rats were divided into control, rotenone (PD), and rotenone plus oxyresveratrol (OXY) groups. The OXY rats received oxyresveratrol (300 mg/kg orally) on days 1-20. Rotenone (3 mg/kg subcutaneously) was given to PD and OXY rats on days 15, 16, 18, and 20. Motor function was determined by the rotarod test. Brains were collected to analyze dopaminergic neurons, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) and catalase activities. OXY rats exhibited a longer latency to fall than PD rats in the rotarod test (P < 0.01) on day 16. The number of dopaminergic neurons in PD rats was lower than that in controls (P < 0.01), while that of OXY rats was not different from controls. OXY rats showed a reduction in MDA levels (P < 0.01) and increased catalase activity (P < 0.05), while SOD activity was unaltered. The results suggest that oxyresveratrol pretreatment ameliorates motor impairment induced by rotenone and preserves dopaminergic neurons. The neuroprotective mechanism of oxyresveratrol is involved with its antioxidant properties.

据报道，白藜芦醇是一种多酚化合物，具有抗氧化和消炎作用。这项研究确定了从白果心果心木中提取的氧白藜芦醇的神经保护作用。Roxburgh（桑科），关于鱼藤酮引起的帕金森病。将雄性Wistar大鼠分为对照组，鱼藤酮（PD）和鱼藤酮加氧白藜芦醇（OXY）组。OXY大鼠在第1-20天接受羟白藜芦醇（口服300 mg / kg）。在第15、16、18和20天对PD和OXY大鼠给予鱼藤酮（3 mg / kg皮下注射）。收集大脑以分析多巴胺能神经元，丙二醛（MDA）水平，超氧化物歧化酶（SOD）和过氧化氢酶活性。在第16天，OXY大鼠在旋转试验中表现出比PD大鼠更长的跌倒潜伏期（P <0.01）。PD大鼠中多巴胺能神经元的数量低于对照组（P<0.01），而OXY大鼠的与对照组无差异。OXY大鼠显示MDA水平降低（P <0.01）和过氧化氢酶活性增加（P <0.05），而SOD活性未改变。结果表明，氧白藜芦醇预处理可改善鱼藤酮引起的运动障碍并保留多巴胺能神经元。氧白藜芦醇的神经保护机制与其抗氧化特性有关。