Since the introduction of the first monoclonal antibody, biopharmaceuticals and biotherapeutic products manufactured in cellular factories are on the rise in modern medicine and therapeutics. Dynamic and real-time innovation strategies for operational implementation of biotherapeutic production are rapidly emerging. The advances in related fields such as genome editing technology, systems biology, and machine learning/artificial intelligence are expected to introduce innovative solutions in every aspect of the mammalian cell culture-based biotherapeutic production. This conceptual review offers a synthesis of the prospects and challenges of integration of multiomics technologies, and an integrative biology vision to cellular factories and biotherapeutic innovation.

中文翻译：

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代谢工程中的生物治疗产品、细胞工厂和多组学整合

自从引入第一个单克隆抗体以来，细胞工厂生产的生物药物和生物治疗产品在现代医学和治疗学中呈上升趋势。用于生物治疗生产运营实施的动态和实时创新战略正在迅速出现。基因组编辑技术、系统生物学和机器学习/人工智能等相关领域的进步有望在基于哺乳动物细胞培养的生物治疗生产的各个方面引入创新解决方案。这篇概念性综述综合了多组学技术整合的前景和挑战，以及对细胞工厂和生物治疗创新的综合生物学愿景。