We thank Alquicira-Hernandez et al. for their reanalysis of our single-cell transcriptomic dataset profiling peripheral immune responses to severe COVID-19. We agree that careful analysis of single-cell sequencing data is important for generating cogent hypotheses but find several aspects of their criticism of our analysis to be problematic. Here we respond briefly to misunderstandings and inaccuracies in their commentary that may have led to misinformed interpretation of our results.

中文翻译：

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进一步分析探讨重度COVID-19中浆母细胞向中性粒细胞发育的假设转分化

我们感谢Alquicira-Hernandez等。重新分析了我们对严重COVID-19的外周免疫应答的单细胞转录组数据集。我们同意对单细胞测序数据进行仔细的分析对于产生有说服力的假设很重要，但是发现它们对我们分析的批评有几个方面是有问题的。在这里，我们对评论中的误解和不准确之处做出简短回应，这可能导致我们对结果的误解。