The recent Coronavirus Disease 2019 (COVID-19) causes an immense health crisis to global public health. The COVID-19 is the etiologic agent of a recently arose disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Presently, there is no vaccine available against this emerged viral disease. Therefore, it is indeed a need of the hour to develop an effectual and safe vaccine against this decidedly pandemic disease. In the current study, we collected SARS-CoV-2 genome which is prominent in India against human host, further more using reverse vaccinology here we claim effective vaccine candidates that can be mile stone in battle against COVID19. This novel study divulged one promising antigenic peptide GVYFASTEK from surface glycoprotein (protein accession no. - QIA98583.1) of SARS-CoV-2, which was predicated to be interacted with MHC alleles and showed up to 90% conservancy and high value of antigenicity. Subsequently, the molecular docking and simulation studies were verified molecular interaction of this prime antigenic peptide with the residues of HLA-A*11-01 allele for MHC Class I. After vigorous analysis, this peptide was predicted to be suitable epitope which is capable to induce the strong cell-mediated immune response against the SARS-CoV-2. Consequences from the current study could facilitate selecting SARS-CoV-2 epitopes for vaccine production pipelines in the immediate future. This novel research will certainly pave the way for a fast, reliable and virtuous platform to provide timely countermeasure of this dangerous pandemic disease, COVID-19.

中文翻译：

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识别针对SARS-CoV-2的潜在候选疫苗，与COVID-19对抗的一步：反向疫苗学方法

最近的2019年冠状病毒病（COVID-19）对全球公共卫生造成了巨大的健康危机。COVID-19是由严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）引起的最近出现的疾病的病原体。当前，没有针对这种新出现的病毒性疾病的疫苗。因此，确实确实需要一个小时来开发一种针对这种确诊的大流行性疾病的有效且安全的疫苗。在当前的研究中，我们收集了SARS-CoV-2基因组，该基因组在印度对人类宿主具有显着的优势，在这里进一步使用反向疫苗学，我们声称有效的候选疫苗可以与COVID19作战。这项新颖的研究从SARS-CoV-2的表面糖蛋白（蛋白登录号-QIA98583.1）中揭示了一种很有前途的抗原肽GVYFASTEK，据推测与MHC等位基因相互作用，显示出高达90％的保守性和高抗原性值。随后，进行了分子对接和模拟研究，验证了该主要抗原肽与MHC I类的HLA-A * 11-01等位基因残基的分子相互作用。经过大量分析，该肽被认为是合适的表位，能够对诱导针对SARS-CoV-2的强烈细胞介导的免疫反应。当前研究的结果可能有助于在不久的将来为疫苗生产管道选择SARS-CoV-2表位。这项新颖的研究无疑将为快速，可靠和良好的平台铺平道路，以便为这种危险的大流行性疾病COVID-19提供及时的对策。