In this work, we describe the CRIMSON (CardiovasculaR Integrated Modelling and SimulatiON) software environment. CRIMSON provides a powerful, customizable and user-friendly system for performing three-dimensional and reduced-order computational haemodynamics studies via a pipeline which involves: 1) segmenting vascular structures from medical images; 2) constructing analytic arterial and venous geometric models; 3) performing finite element mesh generation; 4) designing, and 5) applying boundary conditions; 6) running incompressible Navier-Stokes simulations of blood flow with fluid-structure interaction capabilities; and 7) post-processing and visualizing the results, including velocity, pressure and wall shear stress fields. A key aim of CRIMSON is to create a software environment that makes powerful computational haemodynamics tools accessible to a wide audience, including clinicians and students, both within our research laboratories and throughout the community. The overall philosophy is to leverage best-in-class open source standards for medical image processing, parallel flow computation, geometric solid modelling, data assimilation, and mesh generation. It is actively used by researchers in Europe, North and South America, Asia, and Australia. It has been applied to numerous clinical problems; we illustrate applications of CRIMSON to real-world problems using examples ranging from pre-operative surgical planning to medical device design optimization. CRIMSON binaries for Microsoft Windows 10, documentation and example input files are freely available for download from www.crimson.software, and the source code with compilation instructions is available on GitHub https://github.com/carthurs/CRIMSONFlowsolver (CRIMSON Flowsolver) under the GPL v3.0 license, and https://github.com/carthurs/CRIMSONGUI (CRIMSON GUI), under the AGPL v3.0 license. Support is available on the CRIMSON Google Groups forum, located at https://groups.google.com/forum/#!forum/crimson-users.

中文翻译：

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CRIMSON：用于心血管集成建模和仿真的开源软件框架

在这项工作中，我们描述了CRIMSON（心血管集成建模和仿真）软件环境。CRIMSON提供了一个功能强大，可定制且用户友好的系统，可通过管道执行三维三维降阶计算血流动力学研究，其中包括：1）从医学图像中分割血管结构；2）建立动静脉几何分析模型；3）进行有限元网格生成；4）设计，和5）应用边界条件；6）运行具有流体-结构相互作用能力的不可压缩的Navier-Stokes模拟血流；7）对结果进行后处理和可视化，包括速度，压力和壁切应力场。CRIMSON的主要目标是创建一个软件环境，使强大的计算血液动力学工具可供我们的研究实验室以及整个社区的广大受众使用，包括临床医生和学生。总体理念是利用一流的开源标准进行医学图像处理，并行流计算，几何实体建模，数据同化和网格生成。欧洲，北美和南美，亚洲和澳大利亚的研究人员都在积极使用它。它已被应用于许多临床问题。我们使用从术前手术计划到医疗设备设计优化的实例说明CRIMSON在实际问题中的应用。适用于Microsoft Windows 10的CRIMSON二进制文件，文档和示例输入文件可从www.crimson.software免费下载，带有编译说明的源代码可在GPL v3.0许可下的GitHub https://github.com/carthurs/CRIMSONFlowsolver（CRIMSON Flowsolver）上获得。以及https://github.com/carthurs/CRIMSONGUI（CRIMSON GUI）（根据AGPL v3.0许可）。可通过位于https://groups.google.com/forum/#!forum/crimson-users的CRIMSON Google网上论坛获得支持。