An unprecedented spread of mosquito-borne viruses and increasing populations of mosquito vectors has led to an increase in the frequency of mosquito-borne virus disease outbreaks. Recent outbreaks of Zika virus (ZIKV) and yellow fever virus (YFV), among others have led to a concerted effort to understand the biology of mosquito-borne viruses and their interaction with their vector mosquito and vertebrate hosts. Recent studies have aimed to understand the vector-host-pathogen interface and how it influences infection, tropism and disease severity in the vertebrate host. The initial replication of the pathogen at the skin bite site is crucial in determining the progression of the infection in the vertebrate host. Delineating the role of the commensal microbes in the mosquito saliva as well as how they interact with the vertebrate host keratinocytes will improve our understanding of disease immunopathology and may lead to new therapeutics.

蚊媒病毒的空前传播和蚊媒数量的增加导致蚊媒病毒疾病暴发的频率增加。最近爆​​发的寨卡病毒（ZIKV）和黄热病病毒（YFV）等导致人们共同努力，了解了蚊媒病毒的生物学特性及其与媒介蚊子和脊椎动物宿主的相互作用。最近的研究旨在了解载体-宿主-病原体的界面，以及它如何影响脊椎动物宿主的感染，嗜性和疾病严重性。病原体在皮肤叮咬部位的初始复制对于确定脊椎动物宿主感染的进展至关重要。