Resistance to carbapenems due to carbapenemase-producing Enterobacteriaceae (CPE) is an increasing threat to human health worldwide. In recent years, CPE could be found only sporadically from livestock, but concern rose that livestock might become a reservoir for CPE. In 2019, the first GES carbapenemase-producing Escherichia coli from livestock was detected within the German national monitoring on antimicrobial resistance. The isolate was obtained from pig feces and was phenotypically resistant to meropenem and ertapenem. The isolate harbored three successive bla_GES genes encoding for GES-1, GES-5 and GES-5B in an incomplete class-I integron on a 12 kb plasmid (pEC19-AB02908; Acc. No. MT955355). The strain further encoded for virulence-associated genes typical for uropathogenic E. coli, which might hint at an increased pathogenic potential. The isolate produced the third carbapenemase detected from German livestock. The finding underlines the importance CPE monitoring and detailed characterization of new isolates.

中文翻译：

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首次从家畜中检测生产GES-5的大肠杆菌-德国猪生产中认可的碳青霉烯酶多样性不断增加

产生碳青霉烯酶的肠杆菌科（CPE）对碳青霉烯类药物的耐药性正在全球范围内威胁着人类健康。近年来，仅偶尔从牲畜中发现了CPE，但人们越来越担心牲畜可能成为CPE的储存库。2019年，在德国国家抗微生物药物耐药性监测中发现了首个从牲畜中产生GES碳青霉酶的大肠杆菌。该分离物得自猪粪便，对美罗培南和厄他培南具有表型抗性。隔离株连续三个bla _GES基因在12 kb质粒上以不完整的I类整合子编码GES-1，GES-5和GES-5B（pEC19-AB02908；注册号MT955355）。该菌株还编码了尿毒症大肠杆菌典型的毒力相关基因，这可能暗示了潜在的致病性增加。分离株产生了从德国牲畜中检测到的第三种碳青霉烯酶。该发现强调了CPE监测和新分离株详细表征的重要性。