The exposome has been recognized as an important dimension in understanding human disease and complementing the genome but remains largely uncharacterized. We analyzed 295 matched maternal and cord blood samples using non-targeted high-resolution mass spectrometry and characterized exposome features. We compared the chemical enrichment of the maternal and cord blood samples using a similarity network analysis and examined the interactions between the exogenous and the endogenous chemical features using a molecular interaction networks approach. We detected over 700 chemical features in the maternal and cord pairs and we found that maternal samples are more similar in terms of chemical enrichment to their corresponding cord samples compared to other maternal samples or other cord samples. We observed significant associations between 3 poly/perfluoroalkyl substances (PFAS) and endogenous fatty acids in both the maternal and cord samples indicating important interactions between PFAS and fatty acid regulating proteins. To our knowledge, this is the first non-targeted analysis study that uses such large cohort to characterize the prenatal exposome.

中文翻译：

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产前暴露的全面非目标分析揭示了母体和胎儿样品之间化学富集的显着差异

该暴露小体被认为是了解人类疾病和补充基因组的一个重要方面，但仍未完全表征。我们使用非靶向高分辨率质谱分析了295个匹配的母体和脐带血样品，并表征了暴露体特征。我们使用相似性网络分析比较了母体和脐带血样品的化学富集，并使用分子相互作用网络方法检查了外源性和内源性化学特征之间的相互作用。我们在母体和脐带对中检测到700多种化学特征，发现与其他母体样品或其他脐带样品相比，母体样品在化学富集方面与其对应的脐带样品更为相似。我们在母体和脐带样品中观察到3种聚/全氟烷基物质（PFAS）与内源性脂肪酸之间的显着关联，表明PFAS与脂肪酸调节蛋白之间存在重要的相互作用。据我们所知，这是第一个使用如此大的队列来表征产前暴露体的非靶向分析研究。