A high-stringency blueprint of the human proteome,Nature Communications

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A high-stringency blueprint of the human proteome
Nature Communications ( IF 16.6 ) Pub Date : 2020-10-16 , DOI: 10.1038/s41467-020-19045-9
Subash Adhikari ₁ , Edouard C Nice _{1,

2} , Eric W Deutsch ₃ , Lydie Lane ₄ , Gilbert S Omenn ₅ , Stephen R Pennington ₆ , Young-Ki Paik ₇ , Christopher M Overall ₈ , Fernando J Corrales ₉ , Ileana M Cristea ₁₀ , Jennifer E Van Eyk ₁₁ , Mathias Uhlén ₁₂ , Cecilia Lindskog ₁₃ , Daniel W Chan ₁₄ , Amos Bairoch ₄ , James C Waddington ₆ , Joshua L Justice ₁₀ , Joshua LaBaer ₁₅ , Henry Rodriguez ₁₆ , Fuchu He ₁₇ , Markus Kostrzewa ₁₈ , Peipei Ping ₁₉ , Rebekah L Gundry ₂₀ , Peter Stewart ₂₁ , Sanjeeva Srivastava ₂₂ , Sudhir Srivastava ₂₃ , Fabio C S Nogueira ₂₄ , Gilberto B Domont ₂₄ , Yves Vandenbrouck ₂₅ , Maggie P Y Lam _{26,

27} , Sara Wennersten ₂₈ , Juan Antonio Vizcaino ₂₉ , Marc Wilkins ₃₀ , Jochen M Schwenk ₁₂ , Emma Lundberg ₁₂ , Nuno Bandeira ₃₁ , Gyorgy Marko-Varga ₃₂ , Susan T Weintraub ₃₃ , Charles Pineau ₃₄ , Ulrike Kusebauch ₃ , Robert L Moritz ₃ , Seong Beom Ahn ₁ , Magnus Palmblad ₃₅ , Michael P Snyder ₃₆ , Ruedi Aebersold _{3,

37} , Mark S Baker _{1,

36}

Affiliation

Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
Faculty of Medicine, Nursing and Health Sciences, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia.
Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.
Faculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU, Michel-Servet 1, 1211, Geneva, Switzerland.
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109-2218, USA.
UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
Yonsei Proteome Research Center, 50 Yonsei-ro, Sudaemoon-ku, Seoul, 120-749, South Korea.
Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.
Functional Proteomics Laboratory, Centro Nacional de Biotecnología-CSIC, Proteored-ISCIII, 28049, Madrid, Spain.
Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Cedars Sinai Medical Center, Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Los Angeles, CA, 90048, USA.
Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden.
Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden.
Department of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Biodesign Institute, Arizona State University, Tempe, AZ, USA.
Office of Cancer Clinical Proteomics Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Bruker Daltonik GmbH, Microbiology and Diagnostics, Fahrenheitstrasse, 428359, Bremen, Germany.
Cardiac Proteomics and Signaling Laboratory, Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
CardiOmics Program, Center for Heart and Vascular Research, Division of Cardiovascular Medicine and Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
Department of Chemical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
Cancer Biomarkers Research Branch, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Suite 5E136, Rockville, MD, 20852, USA.
Proteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveria Ramos, 149, 21941-909, Rio de Janeiro, RJ, Brazil.
University of Grenoble Alpes, Inserm, CEA, IRIG-BGE, U1038, 38000, Grenoble, France.
Departments of Medicine-Cardiology and Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Consortium for Fibrosis Research and Translation, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Division of Cardiology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
Department of Computer Science and Engineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0404, La Jolla, CA, 92093-0404, USA.
Department of Biomedical Engineering, Lund University, Lund, Sweden.
Department of Biochemistry and Structural Biology, University of Texas Health Science Center San Antonio, UT Health, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA.
University of Rennes, Inserm, EHESP, IREST, UMR_S 1085, F-35042, Rennes, France.
Leiden University Medical Center, Leiden, 2333, The Netherlands.
Department of Genetics, Stanford School of Medicine, Stanford, CA, 94305, USA.
Faculty of Science, University of Zurich, Zurich, Switzerland.

The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP’s tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.

中文翻译：

人类蛋白质组的高严格蓝图

人类蛋白质组组织 (HUPO) 于 2010 年启动了人类蛋白质组计划 (HPP)，为全球合作、数据共享、质量保证和增强基因组编码蛋白质组的准确注释创建了一个国际框架。在接下来的十年中，HPP 建立了合作，制定了指导方针和指标，并对之前存放的社区数据进行了重新分析，不断扩大了人类蛋白质组的覆盖范围。在 HPP 成立十周年之际，我们在此报告了 90.4% 完整的高严格人类蛋白质组蓝图。这些知识对于辨别健康和疾病的分子过程至关重要，正如我们通过强调人类蛋白质组在我们理解、诊断和治疗癌症、心血管和传染病中所发挥的潜在作用所证明的那样。

更新日期：2020-10-17

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