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Lanthanide-Doped Upconversion Nanoparticles Meet the Needs for Cutting-Edge Bioapplications: Recent Progress and Perspectives
ACS Materials Letters ( IF 9.6 ) Pub Date : 2020-10-16 , DOI: 10.1021/acsmaterialslett.0c00377 Zhijun Zhang 1 , Qinyu Han 2 , Jun Wei Lau 2 , Bengang Xing 2, 3
ACS Materials Letters ( IF 9.6 ) Pub Date : 2020-10-16 , DOI: 10.1021/acsmaterialslett.0c00377 Zhijun Zhang 1 , Qinyu Han 2 , Jun Wei Lau 2 , Bengang Xing 2, 3
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The rise of biological frontier fields such as precision theranostics, gene editing, optogenetics, etc. introduces the best opportunities and unprecedented challenges at the same time to the bioapplication of luminescent nanomaterials. Because of the merits of photon upconversion characteristics and high stability, tunable structure and excitation dynamics, and sharp emissions, the lanthanide-doped upconversion nanoparticle (UCNP) is considered to be a highly competitive candidate to meet these challenges. Indeed, UCNPs have attracted extensive attention in diverse cutting-edge bioapplication fields ranging from near-zero background biosensing, deep tissue bioimaging, precision nanomedicine, and remote biomanipulation since the first development in the early 2000s. Recently, with the increasing maturity of upconversion synthesis technology and the deep integration of multiple disciplines, the biological application research of upconversion has achieved many new breakthroughs. Herein, we summarize the latest bioapplication research progress of UCNPs in the fields of sensing, imaging, therapy, optogenetics, etc. Ultimately, current challenges and perspectives in this field are discussed.
中文翻译：
镧系元素掺杂的上转换纳米颗粒满足尖端生物应用的需求：最新进展和观点
精确治疗论，基因编辑，光遗传学等生物学前沿领域的兴起，为发光纳米材料的生物应用带来了最佳机遇和前所未有的挑战。由于具有光子上转换特性和高稳定性，可调谐的结构和激发动力学以及尖锐的发射的优点，掺杂镧系元素的上转换纳米粒子（UCNP）被认为是应对这些挑战的极具竞争力的候选人。的确，自2000年代初期以来，UCNP在近乎零背景生物传感，深层组织生物成像，精密纳米医学和远程生物操纵等各种前沿生物应用领域中都引起了广泛关注。最近，随着上转换合成技术的日趋成熟和多学科的深度融合，上转换的生物学应用研究取得了许多新的突破。在这里，我们总结了UCNPs在传感，成像，治疗，光遗传学等领域的最新生物应用研究进展。最后，讨论了该领域的当前挑战和前景。
更新日期：2020-11-02
中文翻译：
镧系元素掺杂的上转换纳米颗粒满足尖端生物应用的需求：最新进展和观点
精确治疗论，基因编辑，光遗传学等生物学前沿领域的兴起，为发光纳米材料的生物应用带来了最佳机遇和前所未有的挑战。由于具有光子上转换特性和高稳定性，可调谐的结构和激发动力学以及尖锐的发射的优点，掺杂镧系元素的上转换纳米粒子（UCNP）被认为是应对这些挑战的极具竞争力的候选人。的确，自2000年代初期以来，UCNP在近乎零背景生物传感，深层组织生物成像，精密纳米医学和远程生物操纵等各种前沿生物应用领域中都引起了广泛关注。最近，随着上转换合成技术的日趋成熟和多学科的深度融合，上转换的生物学应用研究取得了许多新的突破。在这里，我们总结了UCNPs在传感，成像，治疗，光遗传学等领域的最新生物应用研究进展。最后，讨论了该领域的当前挑战和前景。
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