Abstract

Psephellus appendicigerus, is a plant endemic to Turkey, belonging to the Asteraceae family, which is traditionally used in folk medicine in Turkey. The aim of this study is to reveal for the first time the biological activities of this plant and evaluate its potential use as a natural product. For this reason, different extracts (ethanol, methanol, ethyl acetate, and hexane) of the plant’s aerial parts were used in determining the antioxidant (2,20-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid and 1,1-diphenyl-2-picrylhydrazyl assays), antimicrobial (disc diffusion and microdilution methods), and enzyme inhibition activity (calorimetric methods) related to diabetes (α-amylase and α-glucosidase). Moreover, the phenolic constituents were analysed by high performance liquid chromatography. Methanol extract of the plant exhibited significant biological activity compared to other extracts. This extract had the highest amount of chlorogenic acid as phenolic compound. In addition, all extracts showed inhibition against at least one test microorganism. According to the results, P. appendicigerus has the potential to be used as a natural antioxidant, antimicrobial and enzyme inhibitor.

摘要

黄芪，是土耳其特有的植物，属于菊科，在土耳其传统上用于民间医学。本研究的目的是首次揭示这种植物的生物活性，并评估其作为天然产品的潜在用途。为此，植物地上部分的不同提取物（乙醇、甲醇、乙酸乙酯和己烷）用于测定抗氧化剂（2,20-叠氮基-双（3-乙基苯并噻唑啉-6-磺酸和 1,1- diphenyl-2-picrylhydrazyl 测定）、抗菌（圆盘扩散法和微量稀释法）和与糖尿病相关的酶抑制活性（量热法）（α-淀粉酶和α-葡萄糖苷酶）。此外，酚类成分通过高效液相色谱分析. 与其他提取物相比，该植物的甲醇提取物表现出显着的生物活性。该提取物作为酚类化合物的绿原酸含量最高。此外，所有提取物都显示出对至少一种测试微生物的抑制作用。根据结果​​，P. appendicigerus具有用作天然抗氧化剂、抗菌剂和酶抑制剂的潜力。