Abstract

Aim

The aim of this study was to make a volumetric comparison of some medial temporal lobe structures and neuropeptides between the patients of Alzheimer’s disease (AD) and healthy individuals.

Method

The study comprised of a group of patients diagnosed with mild AD (n:15) and a Control group (n:15) (16 females, 14 males, mean age:72.90 ± 4.50). Voxel-based morphometry and MRICloud analyses were performed on the MR images taken in 3D measurements of gray matter volumes of all subjects. Following a 10-minute hug test, blood samples were taken from all participants for oxytocin (OT) and arginine vasopressin (AVP) analyses.

Results

The patient group had a statistically lower right hippocampus volume (p = 0.004) and OT values (p = 0.028) than the Control group. OT signal values increased with a volume increase in the right parahippocampal gyrus (PHG_R), and OT conc. and AVP conc. values increased with increasing volume of the PHG_R.

Conclusion

It is suggested that the right hippocampus, right fusiform gyrus, left amygdala, left parahippocampal gyrus, and left entorhinal cortex atrophies can be used as predictors in the early diagnosis of AD. The positive correlation between PHG_R and neuropeptides showed the need to investigate the PHG and OT function more deeply.

中文翻译：

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阿尔茨海默病患者与健康人颞叶切片体积及神经肽作用的比较研究

摘要

目标

本研究的目的是对阿尔茨海默病 (AD) 患者和健康个体之间的一些内侧颞叶结构和神经肽进行体积比较。

方法

该研究由一组被诊断为轻度 AD 的患者 (n:15) 和一个对照组 (n:15) 组成（16 名女性，14 名男性，平均年龄：72.90 ± 4.50）。对所有受试者灰质体积的 3D 测量中拍摄的 MR 图像进行基于体素的形态测量和 MRICloud 分析。在进行了 10 分钟的拥抱测试后，从所有参与者身上采集血样进行催产素 (OT) 和精氨酸加压素 (AVP) 分析。

结果

患者组的右海马体积 ( p  = 0.004) 和 OT 值 ( p  = 0.028) 低于对照组。OT 信号值随着右侧海马旁回 (PHG_R) 和 OT 浓度的增加而增加。和 AVP 浓度。值随着 PHG_R 体积的增加而增加。

结论

提示右侧海马、右侧梭状回、左侧杏仁核、左侧海马旁回、左侧内嗅皮质萎缩可作为AD早期诊断的预测指标。PHG_R与神经肽之间的正相关表明需要更深入地研究PHG和OT功能。