Abstract Biofilm production, hitherto an uncharacterized feature among circulating Pasteurella multocida strains, was studied along with the antibiotic susceptibility pattern. On the basis of biofilm formation ability, all the strains were categorized into four groups under six different culture conditions: strong biofilm-forming (22%), moderate (19%), weak (51%), and non-adherent (7%). Strains from serogroups A and B formed significant biofilms in at least one culture condition whereas strains from serogroup D were unable to form biofilms. All strains were found to be susceptible to tetracycline. In addition, the correlation between diverse factors (host, capsule type, clinical condition and the tadD gene) as well as antimicrobial susceptibility in biofilm production were analyzed by Joint distribution models, and showed that enrofloxacin and azithromycin resistant strains were positively correlated with strong biofilm production.

中文翻译：

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多杀巴斯德氏菌菌株体外生物膜产生和抗菌敏感性模式的变异性

摘要 生物膜生产是循环多杀巴斯德氏菌菌株中迄今未表征的特征，与抗生素敏感性模式一起进行了研究。根据生物膜形成能力，所有菌株在六种不同培养条件下分为四组：强生物膜形成（22%）、中等（19%）、弱（51%）和非粘附（7%） ）。来自血清群 A 和 B 的菌株在至少一种培养条件下形成了显着的生物膜，而来自血清群 D 的菌株无法形成生物膜。发现所有菌株都对四环素敏感。此外，通过联合分布模型分析了多种因素（宿主、胶囊类型、临床状况和 tadD 基因）以及生物膜产生中的抗菌敏感性之间的相关性，