Abstract This study investigated the effect of the quorum sensing molecules (QSMs) farnesol, 2-phenylehtanol, tyrosol and tryptophol against planktonic cells, filamentation and biofilms of Sporothrix spp. The antifungal activity of QSMs was evaluated by broth microdilution. QSMs showed MICs in the ranges of 0.01-1 µM (farnesol), 1-8 mM (2-phenylehtanol and tyrosol), and >16 mM (tryptophol). Filamentous biofilm formation was inhibited by farnesol and 2-phenylehtanol and stimulated by tyrosol. Yeast biofilm formation was inhibited by 2-phenylehtanol and tyrosol. Tryptophol did not affect Sporothrix biofilm formation. QSMs showed MICs against mature biofilms of 8-32 µM (farnesol), 8-32 mM (2-phenylehtanol) and 64-128 mM (tyrosol). In conclusion, farnesol, 2-phenylethanol and tyrosol have antifungal activity against planktonic and sessile cells and modulate filamentation and biofilm formation in Sporothrix spp.

中文翻译：

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外源性真菌群体感应分子抑制浮游细胞生长并调节申克孢子丝菌复合物中的成丝和生物膜形成

摘要 本研究调查了群体感应分子 (QSM) 法尼醇、2-苯乙醇、酪醇和色氨酸对孢子丝菌属的浮游细胞、丝状结构和生物膜的影响。QSMs 的抗真菌活性通过肉汤微量稀释来评估。QSM 显示的 MIC 范围为 0.01-1 µM（法呢醇）、1-8 mM（2-苯乙醇和酪醇）和 >16 mM（色氨酸）。丝状生物膜的形成受到法尼醇和 2-苯乙醇的抑制，而酪醇会刺激。酵母生物膜的形成受到 2-苯乙醇和酪醇的抑制。色氨酸不影响孢子丝菌生物膜的形成。QSM 显示针对 8-32 µM（法呢醇）、8-32 mM（2-苯乙醇）和 64-128 mM（酪醇）的成熟生物膜的 MIC。总之，法呢醇，