Sleep is critical for the maintenance of physiological homeostasis and, as such, inadequate sleep beckons a myriad of pathologies. Sleep deprivation is a growing health concern in contemporary society since short sleep durations are associated with increased cardiovascular disease risk and atherosclerotic plaque development. Vascular endothelial dysfunction is an antecedent to atherosclerosis and cardiovascular disease. Herein, we review seminal literature indicating short sleep durations attenuate endothelial function and explore more recent evidence indicating that sleep deprivation perturbs autonomic balance and the circadian rhythmicity of peripheral vascular clock components. We further examine literature that indicates a mechanistic link between short sleep and endothelial dysfunction and subsequent morbidity. Understanding the mechanisms that regulate endothelial function in the context of sleep deprivation facilitates the development and optimization of interventions, such as exercise, that mitigate the ramifications of inadequate sleep on vascular function and cardiovascular and health.

中文翻译：

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睡眠剥夺和内皮功能：使开创性证据与近期观点相一致

睡眠对于维持生理动态平衡至关重要，因此，睡眠不足会导致多种病理。睡眠不足是当代社会日益关注的健康问题，因为睡眠时间短与心血管疾病风险增加和动脉粥样硬化斑块形成有关。血管内皮功能障碍是动脉粥样硬化和心血管疾病的先决条件。在本文中，我们回顾了指示睡眠时间短会削弱内皮功能的开创性文献，并探索了更多的最新证据，这些证据表明睡眠剥夺扰动了自主平衡和周围血管时钟组件的昼夜节律。我们进一步检查表明短期睡眠与内皮功能障碍和随后发病率之间存在机械联系的文献。