Introduction: Formaldehyde (FA) is a common, volatile organic compound used in organic preservation with known health effects of eye, nose, and throat irritation linked to oxidative stress and inflammation. Indeed, long-term FA exposure may provoke skin disorders, cancer, and cardiovascular disease. However, the effects of short-term FA exposure on the vasculature have yet to be investigated. Purpose: We sought to investigate the impact of an acute FA exposure on: 1) macrovascular function in the arm (brachial artery flow-mediated dilation, FMD), 2) microvascular function in the arm (brachial artery reactive hyperemia, RH) and leg (common femoral artery, supine passive limb movement, PLM), and 3) circulating markers of oxidative stress (xanthine oxidase, XO; protein carbonyl, PC; and malondialdehyde, MDA) and inflammation (C-reactive protein, CRP). Methods: Ten (n=10) healthy females (23±1y) were studied before and immediately after a 90-minute FA exposure ([FA]: 197±79ppb) in cadaver dissection laboratories. Results: Brachial artery FMD% decreased following FA exposure (Pre-FA Exp: 9.41±4.21%, Post-FA Exp: 6.74±2.57%, p=0.043), and FMD/Shear decreased following FA exposure (Pre-FA Exp: 0.13±0.07AU, Post-FA Exp: 0.07±0.03AU, p=0.016). The area under the curve for brachial artery RH (Pre-FA Exp: 481±191ml, Post-FA Exp: 499±165ml) and common femoral artery PLM (Pre-FA Exp: 139±95ml, Post-FA Exp: 129±64ml) were unchanged by FA exposure (p>0.05). Circulating MDA increased (Pre-FA Exp: 4.8±1.3µM, Post-FA Exp: 6.3±2.2µM, p=0.047) while XO, PC, and CRP were unchanged by FA exposure (p>0.05). Conclusion: These initial data suggest a short FA exposure can adversely alter vascular function and oxidative stress, influencing cardiovascular health.

中文翻译：

---

成年人急性甲醛暴露引起的血管功能障碍和氧化应激

简介：甲醛（FA）是一种常见的挥发性有机化合物，用于有机保存，具有对眼睛，鼻子和喉咙的刺激性，与氧化应激和炎症相关的已知健康影响。确实，长期暴露于FA可能会引发皮肤疾病，癌症和心血管疾病。然而，短期FA暴露对脉管系统的影响尚待研究。目的：我们寻求研究急性FA暴露对以下方面的影响：1）手臂中的大血管功能（肱动脉血流介导的扩张，FMD），2）手臂中的微血管功能（肱动脉反应性充血，RH）和腿（股动脉，仰卧被动肢体运动，PLM）和3）氧化应激（黄嘌呤氧化酶，XO；羰基蛋白，PC；丙二醛，MDA）和炎症（C反应蛋白，CRP）的循环指标。方法：在尸体解剖实验室进行90分钟FA暴露（[FA]：197±79ppb）之前和之后立即研究了10名（n = 10）健康女性（23±1y）。结果：FA暴露后肱动脉FMD％降低（FA暴露前：9.41±4.21％，FA暴露后：6.74±2.57％，p = 0.043），FA暴露后FMD /剪切降低（FA暴露前： 0.13±0.07AU，FA后：0.07±0.03AU，p ＝ 0.016）。肱动脉RH（FA前：481±191ml，FA后：499±165ml）和股总动脉PLM（FA前：139±95ml，FA后：129±）的曲线下面积暴露于FA（64ml）不变（p> 0.05）。循环MDA增加（FA前：4.8±1.3μM，FA后：6.3±2.2μM，p = 0.047），而XO，PC和CRP因FA暴露而不变（p> 0.05）。结论：