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Genetic diversity of Listeria monocytogenes serotype 1/2a strains collected in Brazil by Multi‐Virulence‐Locus Sequence Typing (MVLST)
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2020-11-22 , DOI: 10.1111/lam.13413
D.A.F. Silva 1 , D.C. Vallim 2 , C.d.O. Rosas 1 , V.M. Mello 1 , M.L.L. Brandão 3 , I. Filippis 4
Affiliation  

Listeria monocytogenes is an opportunistic pathogen with the ability to adapt to different environmental conditions, resulting in safety issues for food producers. Foods contaminated by L. monocytogenes can represent a risk if consumed by susceptible individuals such as elderly, pregnant women and the immunocompromised. The aim of this study was to evaluate the genetic diversity of a collection of L. monocytogenes isolated from different matrices in Brazil during the period of 1979-2015. A total of 51 L. monocytogenes serotype 1/2a strains isolated from clinical samples (n=3) and food samples (n=48) were characterized by Multi-Virulence-Locus Sequence Typing (MVLST). The strains were assigned to nine Virulence Types (VT): VT-11 (n=3, 5.9%), VT-45 (n=27, 52.9%), VT-59 (n=11, 21.6%), VT-68 (n=3, 5.9%), VT-94 (n=2, 3.9%), VT-107 (n=2, 3.9%), VT-184 (n=1, 1.9%), VT-185 (n=1, 1.9%), and VT-186 (n=1, 1.9%); and four of them (VT-11, VT-45, VT-59 and VT-68) have already been associated with cases of listeriosis worldwide. The VT-11, VT-59 (Epidemic Clone V) and VT-186 were identified in blood culture samples, as well as in different classes of foods. It is recommended that the epidemiological surveillance agencies evaluate the risk that foods contaminated with L. monocytogenes VTs pose to susceptible populations.

中文翻译:

通过多毒力位点序列分型 (MVLST) 在巴西收集的单核细胞增生李斯特菌血清型 1/2a 菌株的遗传多样性

单核细胞增生李斯特菌是一种机会性病原体,能够适应不同的环境条件,给食品生产商带来安全问题。如果老年人、孕妇和免疫功能低下的易感人群食用受单核细胞增生李斯特菌污染的食物,则可能存在风险。本研究的目的是评估 1979-2015 年期间从巴西不同基质中分离出的单核细胞增生李斯特氏菌集合的遗传多样性。从临床样品 (n=3) 和食品样品 (n=48) 中分离出的总共 51 株单核细胞增生李斯特氏菌血清型 1/2a 菌株通过多毒力位点序列分型 (MVLST) 进行表征。菌株被分为九种毒力类型 (VT):VT-11 (n=3, 5.9%)、VT-45 (n=27, 52.9%)、VT-59 (n=11, 21.6%)、VT- 68 (n=3, 5.9%), VT-94 (n=2, 3.9%), VT-107 (n=2, 3.9%), VT-184 (n=1, 1.9%)、VT-185 (n=1, 1.9%) 和 VT-186 (n=1, 1.9%);其中四个(VT-11、VT-45、VT-59 和 VT-68)已经与世界范围内的李斯特菌病病例有关。VT-11、VT-59(流行性克隆 V)和 VT-186 在血培养样本以及不同类别的食物中被鉴定出来。建议流行病学监测机构评估受单核细胞增生李斯特菌 VT 污染的食品对易感人群造成的风险。
更新日期:2020-11-22
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