Production of the next‐generation positron nuclide zirconium‐89 ( 89 Zr) guided by Monte Carlo simulation and its good quality for antibody labeling,Journal of Labelled Compounds and Radiopharmaceuticals

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Production of the next‐generation positron nuclide zirconium‐89 ( 89 Zr) guided by Monte Carlo simulation and its good quality for antibody labeling
Journal of Labelled Compounds and Radiopharmaceuticals ( IF 0.9 ) Pub Date : 2020-10-30 , DOI: 10.1002/jlcr.3888
Feng Wang ₁ , Jin Ding ₁ , Xiaoyi Guo ₁ , Teli Liu ₁ , Lixin Ding ₁ , Lei Xia ₁ , Hua Zhu ₁ , Zhi Yang ₁

Affiliation

The next-generation positron zirconium-89(89 Zr, T1/2 = 3.27 days) is a novel nuclide for immuno-PET because of its favorite longer half-life. The aim of this work is to develop optimized methods for routine production and purification of 89 Zr through Monte Carlo (MC) simulation and laboratory experiments. 89 Y(p,n)89 Zr reaction was used for 89 Zr production. Optimized thicknesses of Al degrader (0.11 cm) and 89 Y foil (0.064 cm) were simulated through MC method. 89 Zr (15.0-40.7 mCi) with an average production rate of 0.92 ± 0.12 mCi/μA·h was produced after 1-2 h bombardment at the proton beam energy 20 MeV and current 20 μA. High radio-purity 89 Zr (6.14-26.8 mCi) obtained eluted from hydroxamate resin using 1 mol/L oxalic acid solution, with the concentration of 2.7×104 mCi/L. The gamma spectrum showed that the characteristic peak of 89 Zr were 511 and 909 keV, and no impurities found. [89 Zr]Zr-DFO-trastuzumab was successfully labeled and performed good radiochemical purity (>95%) and stability that showed potential application in tumor molecular imaging.

中文翻译：

蒙特卡罗模拟引导下下一代正电子核素锆-89 ( 89 Zr) 的生产及其良好的抗体标记质量

下一代正电子锆-89(89 Zr, T1/2 = 3.27 天) 是一种用于免疫 PET 的新型核素，因为它具有较长的半衰期。这项工作的目的是通过蒙特卡罗（MC）模拟和实验室实验开发 89 Zr 常规生产和纯化的优化方法。 89 Y(p,n)89 Zr 反应用于生产 89 Zr。通过MC方法模拟了Al降解剂（0.11 cm）和89 Y箔（0.064 cm）的优化厚度。在质子束能量 20 MeV、电流 20 μA 下轰击 1-2 h 后，生成 89 Zr (15.0-40.7 mCi)，平均产率为 0.92 ± 0.12 mCi/μA·h。用1 mol/L草酸溶液从异羟肟酸树脂中洗脱得到高放射性纯度的89 Zr（6.14-26.8 mCi），浓度为2.7×104 mCi/L。 γ能谱显示 89 Zr的特征峰分别为511和909 keV，未发现杂质。 [89 Zr]Zr-DFO-曲妥珠单抗被成功标记，并具有良好的放射化学纯度（>95%）和稳定性，显示出在肿瘤分子成像中的潜在应用。

更新日期：2020-10-30

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