Determining the extent of cryptococcal disease (CD) is key to therapeutic management. Treatment with fluconazole is only recommended for localised pulmonary disease. Induction therapy with amphotericin B (AmB) and flucytosine is recommended for disease at other sites, irrespective of central nervous system (CNS) involvement, but this is not often followed in patients without meningitis. In this study, we compared treatment and mortality between patients with CD of the CNS and other extrapulmonary (OE) sites.

中文翻译：

---

与中枢神经系统疾病相比，其他肺外隐球菌病患者的治疗和死亡率结果

确定隐球菌病 (CD) 的范围是治疗管理的关键。氟康唑治疗仅推荐用于局限性肺部疾病。无论中枢神经系统 (CNS) 是否受累，对于其他部位的疾病，建议使用两性霉素 B (AmB) 和氟胞嘧啶进行诱导治疗，但在没有脑膜炎的患者中通常不采用这种方法。在这项研究中，我们比较了 CNS 和其他肺外 (OE) 部位 CD 患者的治疗和死亡率。