FLASH radiotherapy (RT) can potentially reduce normal tissue toxicity while preserving tumoricidal effectiveness to improve the therapeutic ratio. The key of FLASH for sparing normal tissues is to irradiate tissues with an ultra‐high dose rate (i.e., ≥40 Gy/s), for which proton RT can be used. However, currently available treatment plan optimization method only optimizes the dose distribution and does not directly optimize the dose rate. The contribution of this work to FLASH proton RT is the development of a novel treatment optimization method, that is, simultaneous dose and dose rate optimization (SDDRO), to optimize tissue‐receiving dose rate distribution as well as dose distribution.

中文翻译：

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FLASH质子治疗的同时剂量和剂量率优化（SDDRO）

FLASH放射疗法（RT）可以潜在地降低正常组织的毒性，同时保持杀伤性效果以提高治疗率。保留正常组织的FLASH的关键是以超高剂量率（≥40 Gy / s）照射组织，可以使用质子RT。但是，当前可用的治疗计划优化方法仅优化剂量分布，而不能直接优化剂量率。这项工作对FLASH质子RT的贡献是开发了一种新颖的治疗优化方法，即同时进行剂量和剂量率优化（SDDRO），以优化组织接收剂量率分布以及剂量分布。