The occurrence of seizures at specific times of the day has been consistently observed for centuries in individuals with epilepsy. Electrophysiological recordings provide evidence that seizures have a higher probability of occurring at a given time during the night and day cycle in individuals with epilepsy here referred to as the seizure rush hour. Which mechanisms underlie such circadian rhythmicity of seizures? Why don't they occur every day at the same time? Which mechanisms may underlie their occurrence outside the rush hour? In this commentary, I present a hypothesis: MORE - Molecular Oscillations and Rhythmicity of Epilepsy, a conceptual framework to study and understand the mechanisms underlying the circadian rhythmicity of seizures and their probabilistic nature. The core of the hypothesis is the existence of ~24-hour oscillations of gene and protein expression throughout the body in different cells and organs. The orchestrated molecular oscillations control the rhythmicity of numerous body events, such as feeding and sleep. The concept developed here is that molecular oscillations may favor seizure genesis at preferred times, generating the condition for a seizure rush hour. However, the condition is not sufficient, as other factors are necessary for a seizure to occur. Studying these molecular oscillations may help us understand seizure genesis mechanisms and find new therapeutic targets and predictive biomarkers. The MORE hypothesis can be generalized to comorbidities and the slower multidien (week/month period) rhythmicity of seizures, a phenomenon addressed in another article in this issue of Epilepsia.

中文翻译：

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昼夜节律/多节律分子振荡和癫痫节律（更多）

几个世纪以来，癫痫患者一直观察到在一天中的特定时间发生癫痫发作。电生理记录提供的证据表明，癫痫患者在此称为癫痫发作高峰时间的夜间和白天周期中的特定时间发生癫痫发作的可能性更高。癫痫发作的这种昼夜节律是什么机制？为什么它们不是每天都在同一时间发生？哪些机制可能是他们在高峰时段之外发生的基础？在这篇评论中，我提出了一个假设：更多 - 癫痫的分子振荡和节律，这是一个概念框架，用于研究和理解癫痫的昼夜节律及其概率性质的潜在机制。该假设的核心是在整个身体的不同细胞和器官中，基因和蛋白质表达存在约 24 小时的振荡。精心设计的分子振荡控制着许多身体事件的节律，例如进食和睡眠。这里提出的概念是，分子振荡可能有利于在首选时间发生癫痫发作，从而为癫痫发作高峰时段创造条件。然而，这个条件还不够，因为发生癫痫发作还需要其他因素。研究这些分子振荡可能有助于我们了解癫痫发作的发生机制并找到新的治疗靶点和预测性生物标志物。MORE 假设可以推广到合并症和较慢的多次（周/月）癫痫节律，