Structural and Surface Properties of Polyamidoamine (PAMAM) – Fatty Acid‐based Nanoaggregates Derived from Self‐assembling Janus Dendrimers,ChemNanoMat

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Structural and Surface Properties of Polyamidoamine (PAMAM) – Fatty Acid‐based Nanoaggregates Derived from Self‐assembling Janus Dendrimers
ChemNanoMat ( IF 2.6 ) Pub Date : 2020-10-15 , DOI: 10.1002/cnma.202000498
Mahesh Loku Yaddehige ₁ , Indika Chandrasiri ₁ , Abigail Barker ₁ , Arun K. Kotha ₂ , Jon Steven Dal Williams ₁ , Briana Simms ₁ , Pavel Kucheryavy ₃ , Daniel G. Abebe ₁ , Mahavir B. Chougule ₂ , Davita L. Watkins ₁

Affiliation

This study summarizes the synthesis, characterization, and evaluation of a library of biocompatible self‐assembling Janus dendrimers (JDs) and their resulting nanostructures possessing either a cationic (NH₃⁺), anionic (COO⁻), or neutral (OH) surface. Strategically designed for applications in therapeutic delivery, the dendrimers are comprised of a polyamidoamine (PAMAM) dendron as the hydrophilic portion and fatty acid (FA) functionalized dendrons as the hydrophobic portion. The physicochemical characterization and in vitro cell viability of amphiphilic JDs were performed. Microscopy (TEM) and dynamic light scattering (DLS) analysis indicate the size (i. e., diameters) of spherical nanoaggregates ranging from 40 to 100 nm with zeta‐potential values ranging from −17.9 to +58.7 mV with respect to the terminal functional group of the JD employed. Furthermore, these systems exhibited spherical nanoaggregates with critical aggregate concentrations (CAC) ranging from 2.8 to 7.0 mg/L. At low concentrations (<200 μg/mL), JDs nanoaggregates showed minimal cell growth inhibitory properties in the in vitro testing, demonstrating their safety. The results of this study prove that a simple yet strategic combination of chemically distinctive dendritic segments can afford a versatile library of unique JDs nanoplatforms with excellent potential for biomedical applications.

中文翻译：

自组装Janus树状聚合物衍生的基于氨基酸的纳米聚集体聚酰胺胺（PAMAM）的结构和表面性质

本研究总结了合成，表征，和生物相容的自组装的Janus树枝状聚合物（JDS）和它们的得到的纳米结构具有两种阳离子（NH库的评价₃⁺），阴离子（COO ^-）或中性（OH）表面。有策略地设计用于治疗递送的树枝状聚合物由作为亲水性部分的聚酰胺基胺（PAMAM）树突和作为疏水性部分的脂肪酸（FA）官能化树突组成。两亲JDs的理化特性和体外细胞活力进行了。显微镜（TEM）和动态光散射（DLS）分析表明，球形纳米聚集体的大小（即直径）在40至100 nm之间，相对于Z的末端官能团，ζ电势值在-17.9至+58.7 mV之间。雇用的JD。此外，这些系统还显示出球形纳米聚集体，其临界聚集体浓度（CAC）为2.8至7.0 mg / L。在低浓度（<200μg/ mL）下，JDs纳米聚集体在体外测试中显示出最小的细胞生长抑制特性，证明了它们的安全性。这项研究的结果证明，化学上独特的树枝状链段的简单而又战略性的组合可以提供独特的JDs纳米平台的多功能库，具有出色的生物医学应用潜力。

更新日期：2020-12-07

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