Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy,Advanced Materials

当前位置： X-MOL 学术 › Adv. Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy
Advanced Materials ( IF 27.4 ) Pub Date : 2020-10-16 , DOI: 10.1002/adma.202003214
Shuang Liang _{1,

2} , Xiaoran Deng ₁ , Ping'an Ma _{1,

2} , Ziyong Cheng _{1,

2} , Jun Lin _{1,

2}

Affiliation

Ultrasound (US)‐triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever‐increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low‐intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial‐assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better‐quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

中文翻译：

纳米材料辅助联合声动力学癌症治疗的最新进展

超声（US）触发的声动力疗法（SDT）作为一种有前途的无创治疗方式，近年来受到越来越多的关注。其名为声敏剂的特殊化学试剂由低强度 US 激活，以产生用于肿瘤治疗的致命活性氧 (ROS)。与光疗策略相比，SDT 提供了许多值得注意的机会和好处，例如更深的渗透深度、无光毒性和更少的副作用。尽管如此，先前的研究也证明了其内在的局限性。由于纳米技术的简单工程性质，许多新型纳米平台被应用于这个新兴领域，以解决这些内在障碍并实现持续创新。特别是，SDT 与其他治疗策略的组合已证明相对于单独的单一疗法在提高抗癌活性方面具有更好的功效。因此，有必要总结纳米材料辅助的联合声动力学癌症治疗应用。在此，重点介绍了基于纳米材料工程方法实现协同治疗效果的设计原则。最终目标是激发设计更优质的组合声动力学治疗方案，并为 SDT 促进其未来向临床应用的转变提供创新思路。有必要总结纳米材料辅助的组合声动力学癌症治疗应用。在此，重点介绍了基于纳米材料工程方法实现协同治疗效果的设计原则。最终目标是激发设计更优质的组合声动力学治疗方案，并为 SDT 促进其未来向临床应用的转变提供创新思路。有必要总结纳米材料辅助的组合声动力学癌症治疗应用。在此，重点介绍了基于纳米材料工程方法实现协同治疗效果的设计原则。最终目标是激发设计更优质的组合声动力学治疗方案，并为 SDT 促进其未来向临床应用的转变提供创新思路。

更新日期：2020-11-25

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11