SATB2 (special AT-rich sequence-binding protein 2) is a member of the special AT-rich binding protein family. As a transcription regulator, SATB2 mainly integrates higher-order chromatin organization. SATB2 expression appears to be tissue- and stage-specific, and is governed by several cellular signaling molecules and mediators. Expressed in branchial arches and osteoblast-lineage cells, SATB2 plays a significant role in craniofacial pattern and skeleton development. In addition to regulating osteogenic differentiation, SATB2 also displays versatile functions in neural development and cancer progression. As an osteoinductive factor, SATB2 holds great promise in improving bone regeneration toward bone defect repair. In this review, we have summarized our current understanding of the physiological and pathological functions of SATB2 in craniofacial and skeleton development, neurogenesis, tumorigenesis and regenerative medicine.

SATB2（特殊的富含 AT 的序列结合蛋白 2）是特殊的富含 AT 的结合蛋白家族的成员。作为转录调节因子，SATB2主要整合高阶染色质组织。SATB2 表达似乎是组织和阶段特异性的，并受几种细胞信号分子和介质的控制。SATB2 在鳃弓和成骨细胞系细胞中表达，在颅面模式和骨骼发育中起重要作用。除了调节成骨分化外，SATB2 还在神经发育和癌症进展中显示出多种功能。作为一种骨诱导因子，SATB2 在改善骨再生以修复骨缺损方面具有很大的前景。在本次审查中，