RNA binding proteins (RBPs) are ubiquitously found in all kingdoms of life. They are involved in a plethora of regulatory events, ranging from direct regulation of gene expression to guiding modification of RNA molecules. As bacterial regulators, RBPs can act alone or in concert with RNA-based regulators, such as small regulatory RNAs (sRNAs), riboswitches, or clustered regularly interspaced short palindromic repeats (CRISPR) RNAs. Various functions of RBPs, whether dependent or not on an RNA regulator, have been described in the past. However, the past decade has been a fertile ground for the development of novel high-throughput methods. These methods acted as stepping-stones for the discovery of new functions of RBPs and helped in the understanding of the molecular mechanisms behind previously described regulatory events. Here, we present an overview of the recently identified roles of major bacterial RBPs from different model organisms. Moreover, the tight relationship between RBPs and RNA-based regulators will be explored.

RNA结合蛋白（RBP）在生活的各个王国中普遍存在。它们涉及许多调节事件，从直接调节基因表达到指导RNA分子修饰。作为细菌调节剂，RBP可以单独发挥作用，也可以与基于RNA的调节剂协同作用，例如小调节RNA（sRNA），核糖开关或成簇的规则间隔的短回文重复（CRISPR）RNA。过去已经描述了RBP的各种功能，无论是否依赖于RNA调节剂。但是，过去的十年一直是开发新型高通量方法的沃土。这些方法充当了发现RBP新功能的垫脚石，有助于理解前述调节事件背后的分子机制。这里，我们概述了最近发现的来自不同模式生物的主要细菌RBP的作用。此外，将探索RBP与基于RNA的调节剂之间的紧密关系。