Integral membrane proteins (IMPs) have crucial roles in many cellular processes. A novel intramembrane chaperone complex, recently elucidated by Chitwood and Hedge, provides mechanistic insight of IMP biogenesis and folding, illustrating how IMPs with multiple transmembrane domains (TMDs) are assembled within the endoplasmic reticulum (ER) membrane.

中文翻译：

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ER中的PAT用于跨膜蛋白折叠

整合膜蛋白（IMP）在许多细胞过程中都起着至关重要的作用。最近由Chitwood和Hedge阐明的新型膜内分子伴侣复合物提供了IMP生物发生和折叠的机制性见解，说明了具有多个跨膜结构域（TMD）的IMP如何在内质网（ER）膜内组装。