Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSEs) that affects free-ranging and captive cervid species. The infectious agent of CWD may be transmitted from ingestion of prions shed in bodily fluids (e.g. feces, urine, saliva, placenta tissue) of infected animals, contaminated pastures, and/or decomposing carcasses from dead animals. Studies have also demonstrated prion infectivity in whole blood or blood fractions of CWD infected animals. To determine if CWD-infected blood contained sufficient levels of prion infectivity to cause disease, recipient deer were inoculated intravenously (IV) with blood derived from a CWD-infected white-tailed deer. We found that the CWD agent can be successfully transmitted to white-tailed deer by a single intravenous blood transfusion. The incubation period was associated with recipient prion protein genotype at codon 96 with the GG96 recipient incubating for 25.6 months and the GS96 recipient incubating for 43.6 months. This study complements and supports an earlier finding that CWD can be transmitted to deer by intravenous blood transfusion from white-tailed deer with CWD.

慢性消耗性疾病（CWD）是一种可传播的海绵状脑病（TSE），会影响散养和圈养的子宫颈物种。CWD的传染原可通过摄入感染动物，受污染的牧场和/或分解死者尸体的体液（例如粪便，尿液，唾液，胎盘组织）中释放的病毒而传播。研究还表明，感染了CWD的动物的全血或血液部分具有病毒感染性。为了确定感染了CWD的血液是否包含足以引起疾病的ion病毒感染性水平，将接受CWD感染的白尾鹿的血液静脉内（IV）接种接受鹿。我们发现，通过单次静脉输血可以将CWD剂成功地传播到白尾鹿。潜伏期与密码子96的受体病毒蛋白基因型有关，其中GG96受体孵育25.6个月，GS96受体孵育43.6个月。这项研究补充并支持了先前的发现，即可以通过白尾鹿的CWD静脉输血将CWD传播给鹿。