Objective

Examine subjective sleep quality and inflammation among healthy older adults participating in the Australian Research Council Longevity Intervention (ARCLI).

Methods

Data was taken from a sub-set of 232 participants aged between 60–70 years (M = 65.88 ± SD 4.08 years) who participated in the baseline assessment phase of the Australian Research Council Longevity Intervention (ARCLI) study. Subjective sleep was assessed via the Leeds Sleep Evaluation Questionnaire (LSEQ). Inflammatory markers (TNF-α, IL-1β, IL-6, IL-10, IL-2, IFN-γ, IL-4, hs-CRP) were derived from whole blood. Correlation and multiple regression analyses were used to examine associations between each of the four sleep outcome variables and inflammatory outcomes, examined as a group and following gender stratification.

Results

Difficulties getting to sleep were independently associated with higher IL-2 [F_(1,156) = 4.62, adjusted $R^2$ = 0.02, p = 0.03] and IL-1β [F_(1,141) = 8.52, adjusted $R^2$ = 0.05, p = 0.004] (whole group). Difficulties getting to sleep were associated with greater IL-1β [males: F_(1,58) = 7.36, adjusted $R^2$ = 0.097 p = 0.009; females: F _(1,81) = 4.25, $R^2$ = 0.038, p = 0.04], and negatively associated with hs-CRP (women) [F _(1,129) = 4.71, $R^2$ = 0.028, p = 0.032].

Discussion

Subjective sleep-onset difficulties are associated with systemic inflammation.

中文翻译：

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健康老年人自评睡眠质量差是否与全身炎症升高有关？

客观的

检查参与澳大利亚研究委员会长寿干预 (ARCLI) 的健康老年人的主观睡眠质量和炎症。

方法

数据取自参加澳大利亚研究委员会长寿干预 (ARCLI) 研究基线评估阶段的 232 名年龄在 60-70 岁之间（M = 65.88 ± SD 4.08 岁）的参与者的子集。通过利兹睡眠评估问卷 (LSEQ) 评估主观睡眠。炎症标志物（TNF-α、IL-1β、IL-6、IL-10、IL-2、IFN-γ、IL-4、hs-CRP）来自全血。相关性和多元回归分析用于检查四个睡眠结果变量中的每一个与炎症结果之间的关联，作为一个组进行检查并遵循性别分层。

结果

入睡困难与较高的 IL-2 独立相关 [F _(1,156) = 4.62，调整${\mathrm{电阻}}^2$= 0.02, p = 0.03] 和 IL-1β [F _(1,141) = 8.52, 调整${\mathrm{电阻}}^2$= 0.05，p = 0.004]（整个组）。入睡困难与较高的 IL-1β 相关 [男性：F _(1,58) = 7.36，调整后${\mathrm{电阻}}^2$= 0.097 p = 0.009；女性：F _(1,81) = 4.25,${\mathrm{电阻}}^2$= 0.038, p = 0.04]，与 hs-CRP（女性）负相关 [F _(1,129) = 4.71,${\mathrm{电阻}}^2$= 0.028，p = 0.032]。

讨论

主观入睡困难与全身炎症有关。