Multiple Sclerosis (MS) is one of the leading causes of non-traumatic neurological disability among young adults. Due to its complex pathology and the lack of reliable disease models, there are no effective therapies for MS to prevent neurodegeneration or promote neuroprotection, and hence stop disease progression. The emergence of induced pluripotent stem cells (iPSC) has allowed the generation of patient-specific neural cell types for disease modelling, drug screening, and cell therapy. In this review, the challenges related with the use of iPSC-derived cells in MS are discussed, with a special focus on the functional studies performed, limitations and future perspectives.

中文翻译：

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使用诱导多能干细胞模拟多发性硬化症

多发性硬化症 (MS) 是年轻人非创伤性神经功能障碍的主要原因之一。由于其复杂的病理学和缺乏可靠的疾病模型，MS没有有效的疗法来预防神经变性或促进神经保护，从而阻止疾病进展。诱导多能干细胞 (iPSC) 的出现使得产生用于疾病建模、药物筛选和细胞治疗的患者特异性神经细胞类型成为可能。在这篇综述中，讨论了与在 MS 中使用 iPSC 衍生细胞相关的挑战，特别关注所进行的功能研究、局限性和未来前景。