Mixed germ cell tumours occur rarely in veterinary species. This report describes a case of metastatic mixed germ cell tumour in a female Eurasian harvest mouse (Mycromis minutus). The tumour was extensive in one ovary and the uterus, and was characterized by two distinct tumour cell populations with features typical of embryonal carcinoma (EC) and choriocarcinoma (CC). Metastases of CC to the lungs and liver were observed. The exact origin of the CC was unclear, but the possibility of a non-gestational CC is favoured, given the context of a mixed germ cell tumour and lack of p53 expression. EC diagnosis was confirmed by immunohistochemical labelling of CD30 and lack of immunoreactivity for c-Kit. In addition, membranous β-catenin expression was present in the EC component, indicating an inactive Wnt/β-catenin pathway, which is required for the maintenance of pluripotency.

混合生殖细胞肿瘤很少发生在兽医物种中。本报告描述了雌性欧亚收获小鼠 ( Mycromis minutus)中的一例转移性混合生殖细胞肿瘤）。肿瘤在一个卵巢和子宫中广泛分布，以两种不同的肿瘤细胞群为特征，具有典型的胚胎癌 (EC) 和绒毛膜癌 (CC) 特征。观察到CC向肺和肝的转移。CC 的确切起源尚不清楚，但考虑到混合生殖细胞肿瘤和缺乏 p53 表达的背景，非妊娠 CC 的可能性是有利的。EC 诊断通过 CD30 的免疫组织化学标记和 c-Kit 缺乏免疫反应性得到证实。此外，EC 组分中存在膜状 β-连环蛋白表达，表明 Wnt / β-连环蛋白通路处于非活动状态，这是维持多能性所必需的。