Ensuring the safety of food sources continues to be a priority in animal production. This requires elucidating and utilizing interventions such as bacteriophages (BP) to reduce pathogens such as Salmonella. This study was conducted to evaluate the efficacy of a bacteriophage in the feed for its ability to reduce Salmonella Enteritidis (S.E.) colonization in broilers. Two hundred seventy day-of-hatch broiler chicks were placed into 3 treatments: 1) challenged control, 2) 1 kg BP/metric ton, and 3) 1.5 kg BP/metric ton. Birds were given S.E.-contaminated (10⁵ CFU/g feed) diets from day of trial (DOT) 8 to 14. Both BP treatments significantly reduced S.E. prevalence from cloacal swabs on DOT 14 (P < 0.001). There were no significant differences in liver and spleen S.E. prevalence among treatments on DOT 28. The S.E. prevalence in the ceca was significantly lower (P < 0.001) in both BP treatments on DOT 28. This study demonstrates the efficacy of in-feed BP in reducing S.E.-contamination of feed as it passes the GI tract.

确保食品来源的安全仍然是动物生产中的优先事项。这需要阐明和利用诸如噬菌体（BP）的干预措施来减少诸如沙门氏菌的病原体。这项研究进行评估的饲料其降低能力噬菌体的功效沙门氏菌肠炎（SE肉鸡）定植。将孵化日为270天的肉仔鸡置于3种处理中：1）激发对照，2）1kg BP /公吨，和3）1.5kg BP /公吨。 自试验之日起，家禽就被SE污染（10 ⁵ CFU / g饲料）饮食（DOT））8至14。两种BP治疗均显着降低了DOT 14上泄殖腔拭子引起的SE患病率（P <0.001）。在DOT 28上的治疗之间，肝脏和脾脏SE患病率无显着差异。在两种DOT 28上的BP治疗中，盲肠中的SE患病率均显着较低（P <0.001）。减少饲料通过胃肠道时对SE的污染。