Objective To study pain in women undergoing oocyte retrieval with a reduced needle (20/17 gauge) compared to a standard needle (16 gauge). Design Single-center randomized controlled trial. Setting Fertility clinic. Patients Women undergoing their first oocyte retrieval for in vitro fertilization or intracytoplasmic sperm injection. Interventions Oocyte retrieval with a reduced needle (20/17 gauge) or with a standard needle (16 gauge). Main Outcome Measures The primary outcome measure was intraoperative pain on an 11-point visual analogue scale (VAS). Secondary outcome measures included the following: dosage of fentanyl requested; pain at 5, 15 and 30 minutes after retrieval; and pain and analgesia until 4 days after retrieval. Results A total of 47 women were randomized for the reduced needle (RN) and 48 for the standard needle (SN). Pain scores were significantly lower during and after retrieval with the RN. During retrieval, mean VAS scores in the RN group were 4.3 versus 6.3 in the SN group. Pain remained significantly lower in the RN group after retrieval, with VAS-scores of 1.2 vs. 2.1 directly after retrieval, 0.0 versus 2.0 5 minutes after retrieval, and 0.0 versus 1.0 30 minutes after retrieval. In the RN group, three patients (6.4%) requested more fentanyl during the procedure, versus 16 (33.3%) in the SN group. A total of 79 patients submitted their follow-up questionnaire (response rate 83%). Pain on the first 2 days following retrieval was significantly less in the RN group, with VAS scores of 1.6 versus 2.4 in the SN group, and 1.2 versus 2.5. In line with this finding, fewer patients in the RN group took analgesia on the days after the procedure. This difference was statistically significant only on day 3. Conclusion Use of a thinner needle results in significantly and clinically relevant lower pain scores during oocyte retrieval, and patients in the reduced needle group requested significantly less analgesia during oocyte retrieval than patients in the standard needle group. Pain scores remained significantly lower up until 2 days after the procedure. Dutch Trial Registration Number NTR6064 (www.trialregister.nl).

中文翻译：

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取卵过程中针头直径对疼痛的影响——一项随机对照试验

目的 研究与标准针（16 号）相比，使用缩小针（20/17 号）进行卵母细胞取出的女性的疼痛。设计单中心随机对照试验。设置生育​​诊所。患者 接受第一次取卵以进行体外受精或胞浆内精子注射的女性。干预 使用缩小针头（20/17 号）或标准针头（16 号）取卵。主要结果测量 主要结果测量是 11 点视觉模拟评分 (VAS) 的术中疼痛。次要结果测量包括以下内容：要求的芬太尼剂量；取出后 5、15 和 30 分钟疼痛；疼痛和镇痛直至取回后 4 天。结果共有 47 名女性被随机分配接受减少针头 (RN) 和 48 名女性接受标准针头 (SN)。使用 RN 检索期间和之后的疼痛评分显着降低。在检索过程中，RN 组的平均 VAS 评分为 4.3，而 SN 组为 6.3。取回后 RN 组的疼痛仍然显着降低，取回后的 VAS 评分为 1.2 与 2.1，取回后 5 分钟为 0.0 与 2.0，取回后 30 分钟为 0.0 与 1.0。在 RN 组中，3 名患者（6.4%）在手术过程中要求更多的芬太尼，而 SN 组中为 16 名（33.3%）。共有79名患者提交了他们的随访问卷（回复率为83%）。RN 组取回后前 2 天的疼痛明显减轻，SN 组的 VAS 评分分别为 1.6 和 2.4，以及 1.2 和 2.5。与这一发现一致，RN 组中较少的患者在术后几天服用镇痛药。这种差异仅在第 3 天具有统计学意义。 结论 使用更细的针头导致取卵期间疼痛评分显着降低且具有临床相关性，减少针头组的患者在取卵期间要求的镇痛效果明显低于标准针头组的患者. 直到手术后 2 天，疼痛评分仍然显着降低。荷兰审判注册号 NTR6064 (www.trialregister.nl)。直到手术后 2 天，疼痛评分仍然显着降低。荷兰审判注册号 NTR6064 (www.trialregister.nl)。直到手术后 2 天，疼痛评分仍然显着降低。荷兰审判注册号 NTR6064 (www.trialregister.nl)。