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Fronto-parietal networks underlie the interaction between executive control and conscious perception: Evidence from TMS and DWI
Cortex ( IF 3.6 ) Pub Date : 2020-10-17 , DOI: 10.1016/j.cortex.2020.09.027
Mar Martín-Signes 1 , Cristina Cano-Melle 1 , Ana B Chica 1
Affiliation  

The executive control network is involved in novel situations or those in which prepotent responses need to be overridden. Previous studies have demonstrated that when control is exerted, conscious perception is impaired, and this effect is related to the functional connectivity of fronto-parietal regions. In the present study, we explored the causal involvement of one of the nodes of this fronto-parietal network (the right Supplementary Motor Area, SMA) in the interaction between executive control and conscious perception. Participants performed a dual task in which they responded to a Stroop task while detecting the presence/absence of a near-threshold Gabor stimulus. Concurrently, transcranial magnetic stimulation (TMS) was applied over the right SMA or a control site (vertex; Experiment 1). As a further control, the right Frontal Eye Field (FEF) was stimulated in Experiment 2. Diffusion-weighted imaging (DWI) tractography was used to isolate the three branches of the superior longitudinal fasciculus (SLF I, II and III), and the frontal aslant tract (FAT), and to explore if TMS effects were related to their micro- and macrostructural characteristics. Results demonstrated reduced perceptual sensitivity on incongruent as compared to congruent Stroop trials. A causal role of the right SMA on the modulation of perceptual sensitivity by executive control was only demonstrated when the microstructure of the right SLF III or the left FAT were taken into account. The volume of the right SLF III was also related to the modulation of response criterion by executive control when the right FEF was stimulated. These results add evidence in favor of shared neural correlates for attention and conscious perception in fronto-parietal regions and highlight the role of white matter in TMS effects.



中文翻译:

额顶网络是执行控制与意识感知之间相互作用的基础:TMS和DWI的证据

执行控制网络涉及新颖的情况或需要优先考虑的情况。先前的研究表明,施加控制权会损害意识,这与额顶区域的功能连通性有关。在本研究中,我们探讨了这个额顶网络的节点之一(右辅助运动区,SMA)在执行控制和意识感知之间的相互作用中的因果关系。参与者执行了双重任务,即他们在检测到阈值Gabor刺激的存在/不存在时对Stroop任务做出了响应。同时,经颅磁刺激(TMS)应用于右SMA或对照部位(顶点;实验1)。作为进一步的控制,在实验2中刺激了右额眼视野(FEF)。使用弥散加权成像(DWI)束摄影术来分离上纵筋膜的三个分支(SLF I,II和III)和额叶倾斜道(FAT) ),并探讨TMS效应是否与其微观和宏观结构特征有关。结果表明,与一致的Stroop试验相比,不一致的患者的感知敏感性降低。仅当考虑到右SLF III或左FAT的微观结构时,才证明右SMA对通过执行控制调节感知敏感性的因果作用。当刺激右FEF时,右SLF III的体积也与执行控制对反应标准的调节有关。

更新日期:2020-11-27
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