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Web-based tools for miRNA studies analysis
Computers in Biology and Medicine ( IF 7.7 ) Pub Date : 2020-10-16 , DOI: 10.1016/j.compbiomed.2020.104060
Fatemeh Shaker 1 , Abbas Nikravesh 1 , Roghaye Arezumand 1 , Seyed Hamid Aghaee-Bakhtiari 2
Affiliation  

In recent years, thousands of microRNAs (miRNA) have been found in numerous species. The huge data resulting from miRNA researches are ordered in several levels including miRNA discovery, the sequence of mature and precursor miRNAs, role in diseases, pathway interaction, target validation, and prediction, etc. To prepare a simple approach to this information, numerous databases for miRNA records have been established. The selection of the correct database can be laborious and prolonged, especially for scientists who do not have experience in this field. To facilitate access to these resources, we have classified the available databases into seven categories and have described each one. The different categories of miRNA databanks contain miRNA sequence, target validation, target prediction, expression, function, role in pathways and networks, and their roles in diseases. Moreover, examples are included to describe the prototype databases for the most common applications. Hence, this review introduces available miRNA databases and presents a convenient overview of these databases that will enable researchers with different backgrounds to find suitable miRNA-related bioinformatics web tools and relevant microRNA information rapidly.



中文翻译:

基于Web的miRNA研究分析工具

近年来,在众多物种中发现了数千种microRNA(miRNA)。来自miRNA研究的大量数据按不同级别排序,包括miRNA发现,成熟和前体miRNA的序列,在疾病中的作用,途径相互作用,靶标验证和预测等。要准备一个简单的方法来获取此信息,请使用大量数据库miRNA记录已建立。正确数据库的选择可能会很费力且耗时,特别是对于没有该领域经验的科学家而言。为了方便访问这些资源,我们将可用的数据库分为七个类别,并分别进行了描述。miRNA数据库的不同类别包含miRNA序列,靶标验证,靶标预测,表达,功能,在途径和网络中的作用,及其在疾病中的作用。此外,还包括一些示例来描述最常见应用程序的原型数据库。因此,本综述介绍了可用的miRNA数据库,并对这些数据库进行了方便的概述,这将使具有不同背景的研究人员能够快速找到合适的miRNA相关的生物信息学网络工具和相关的microRNA信息。

更新日期:2020-10-30
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