OBJECTIVE This study examined sensory gating in children with autism spectrum disorders (ASD). Gating is usually examined at the P50 component and rarely at mid- and late-latency components. METHODS Electroencephalography data were recorded during a paired-click paradigm, from 18 children with ASD (5-12 years), and 18 typically-developing (TD) children. Gating was assessed at the P50, N1, P2, and N2 event-related potential components. Parents of all participants completed the Short Sensory Profile (SSP). RESULTS TD children showed gating at all components while children with ASD showed gating only at P2 and N2. Compared to TD children, the ASD group showed significantly reduced gating at P50, N1, and P2. No group differences were found at N2, suggesting typical N2 gating in the ASD group. Time-frequency analyses showed reduced orientation and neural synchronization of auditory stimuli. P50 and N1 gating significantly correlated with the SSP. CONCLUSION Although children with ASD have impaired early orientation and filtering of auditory stimuli, they exhibited gating at P2 and N2 components suggesting use of different gating mechanisms compared to TD children. Sensory deficits in ASD may relate to gating. SIGNIFICANCE The data provide novel evidence for impaired neural orientation, filtering, and synchronization in children with ASD.

中文翻译：

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扩大我们对自闭症谱系障碍儿童感觉门控的理解

目的 本研究检查了自闭症谱系障碍 (ASD) 儿童的感觉门控。门控通常在 P50 组件进行检查，很少在中延迟组件进行检查。方法 在配对点击范例期间记录了来自 18 名 ASD 儿童（5-12 岁）和 18 名正常发育 (TD) 儿童的脑电图数据。在 P50、N1、P2 和 N2 事件相关的潜在组件中评估门控。所有参与者的父母都完成了短感官档案 (SSP)。结果 TD 儿童在所有部分都显示门控，而 ASD 儿童仅在 P2 和 N2 显示门控。与 TD 儿童相比，ASD 组在 P50、N1 和 P2 时显示出显着减少的门控。在 N2 没有发现组间差异，表明 ASD 组是典型的 N2 门控。时频分析显示听觉刺激的定向和神经同步减少。P50 和 N1 门控与 SSP 显着相关。结论 尽管 ASD 儿童的听觉刺激的早期定向和过滤受损，但他们在 P2 和 N2 组件上表现出门控，表明与 TD 儿童相比，他们使用了不同的门控机制。ASD 的感觉缺陷可能与门控有关。意义 该数据为 ASD 儿童的神经定向、过滤和同步受损提供了新的证据。他们展示了 P2 和 N2 组件的门控，表明与 TD 儿童相比，使用了不同的门控机制。ASD 的感觉缺陷可能与门控有关。意义 该数据为 ASD 儿童的神经定向、过滤和同步受损提供了新的证据。他们展示了 P2 和 N2 组件的门控，表明与 TD 儿童相比，使用了不同的门控机制。ASD 的感觉缺陷可能与门控有关。意义 该数据为 ASD 儿童的神经定向、过滤和同步受损提供了新的证据。