Chlorooganic xenobiotics (XBs) such as DDT, DDE, aldrin and dieldrin interfere with release of hormones from chorionic villi that are necessary for sustaining the normal course pregnancy: prostaglandins (PGs), oxytocin (OT), progesterone (P₄) and estradiol (E₂). Approximately 20 %–40 % of these hormones originate from the smooth chorion. The aim of current studies was to investigate effects of these XBs on synthesis and release of PGE₂, PGF_2α, OT, P₄ and E₂ from explants of smooth chorion of cattle, obtained during the120–150 and 151–180 day gestational period. Explants were incubated with DDT, DDE, aldrin or dieldrin at concentrations of 1 and 10 ng/mL for 24 h, and concentrations of PGE₂, PGF_2α, OT, P₄ and E₂ in post incubation medium and the relative abundances of COX-2, PTGES, AKR1B1, NP-I/OT, PAM, HSD3B, and CYP19A1 mRNA transcripts in tissue explants were determined. The XBs did not have effects on cell viability in explants (P > 0.05), however, there were effects on prostaglandins, OT and P₄ secretion and relative abundance of mRNA transcript for genes encoding the main enzymes involved in synthesis of these hormones (P < 0.05). The XBs that were evaluated did not have effects on E₂ synthesis and secretion (P > 0.05). In summary, XBs evaluated in the present study had effects on the pattern of prostaglandin secretion, and can increase OT and P₄ release from smooth chorion explants. Because XBs inhibit hormonal action throughout the chorion, there is an increase in risk of abortions or premature births in animals.

Chlorooganic xenobiotics (XBs) 如 DDT、DDE、艾氏剂和狄氏剂会干扰绒毛膜绒毛释放维持正常妊娠所必需的激素：前列腺素 (PGs)、催产素 (OT)、孕酮 (P ₄ ) 和雌二醇 ( E ₂ )。这些激素中大约 20%–40% 来自光滑的绒毛膜。当前研究的目的是研究这些 XBs 对 PGE ₂、PGF _2α、OT、P ₄和 E ₂合成和释放的影响来自牛的光滑绒毛膜外植体，在妊娠 120-150 天和 151-180 天期间获得。外植体与浓度为 1 和 10 ng/mL 的 DDT、DDE、艾氏剂或狄氏剂一起培养 24 小时，并在培养后培养基中加入 PGE ₂、PGF _2α、OT、P ₄和 E ₂浓度以及COX的相对丰度-2，测定了组织外植体中的PTGES、AKR1B1、NP-I/OT、PAM、HSD3B和CYP19A1 mRNA 转录物。XBs 对外植体的细胞活力没有影响（P  > 0.05），但对前列腺素、OT 和 P ₄有影响编码参与这些激素合成的主要酶的基因的 mRNA 转录物的分泌和相对丰度（P  < 0.05）。被评估的 XBs 对 E ₂合成和分泌没有影响（P  > 0.05）。总之，本研究中评估的 XBs 对前列腺素分泌模式有影响，并且可以增加平滑绒毛膜外植体的OT 和 P ₄释放。由于 XB 会抑制整个绒毛膜的激素作用，因此会增加动物流产或早产的风险。