Synthesis of novel indeno[1,2-c]isoquinoline derivatives, functionalized at the D ring and bearing 1,2,3-triazole unit, has been reported. These hybrid compounds display cytotoxic activity against two human cancer cell lines – KB and HepG2 with half maximal inhibitory concentration (IC₅₀) values in a range of 20–40 μM.

中文翻译：

---

带有酯官能团和1,2,3-三唑部分的茚并[1,2-c]异喹啉衍生物的合成及细胞毒性评价

已经报道了在D环上官能化并带有1,2,3-三唑单元的新型茚并[1,2- c ]异喹啉衍生物的合成。这些杂合化合物对两种人类癌细胞系KB和HepG2表现出细胞毒活性，最大抑菌浓度（IC ₅₀）值的一半在20–40μM范围内。