The antioxidant formulation ethylmethylhydroxypyridine succinate (Mexidol) effectively neutralizes the radiolysis products of water and oxidative damage to DNA and proteins induced by X-irradiation. This substance was found to affect the formation of long-lived reactive forms of albumins and globulins and their degradation, which is accompanied by generation of hydrogen peroxide and an increase in the duration of oxidative stress after irradiation. Ethylmethylhydroxypyridine succinate has gene-protective and radiomitigating actions in vivo, decreasing the formation of micronuclei in polychromatophilic erythrocytes from red bone marrow in mice after irradiation, and is a potential therapeutic radiomitigating agent for preventing adverse effects due to impairments of redox homeostasis after irradiation.

中文翻译：

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X 射线辐射中乙基甲基羟基吡啶琥珀酸酯 (Mexidol) 的抗氧化和基因保护特性

抗氧化配方乙基甲基羟基吡啶琥珀酸酯 (Mexidol) 可有效中和水的辐射分解产物以及 X 射线引起的 DNA 和蛋白质的氧化损伤。发现这种物质会影响白蛋白和球蛋白的长寿命反应形式的形成及其降解，同时伴随着过氧化氢的产生和辐照后氧化应激持续时间的增加。Ethylmethylhydroxypyridine succinate 在体内具有基因保护和放射缓解作用，可减少小鼠红骨髓中多嗜性红细胞在照射后微核的形成，是一种潜在的治疗性放射缓解剂，可预防因照射后氧化还原稳态受损引起的不良反应。