Gold nanoparticle-graphene quantum dots nanozyme for the wide range and sensitive electrochemical determination of quercetin in plasma droplets,Microchimica Acta

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Gold nanoparticle-graphene quantum dots nanozyme for the wide range and sensitive electrochemical determination of quercetin in plasma droplets
Microchimica Acta ( IF 5.3 ) Pub Date : 2020-10-16 , DOI: 10.1007/s00604-020-04587-y
Cristina Stefanov ₁ , Catalina Cioates Negut ₁ , Livia Alexandra Dinu Gugoasa _{1,

2} , Jacobus Koos Frederick van Staden ₁

Affiliation

A gold nanoparticle/graphene quantum dots (AuNP/GQD) nanozyme–modified screen-printed carbon electrode (SPCE) was developed for fast and ultrasensitive determination of quercetin by square-wave voltammetry. The nanosensing device was inserted in miniaturized equipment. Under the optimal experimental conditions, a good linear relationship between oxidation peak current and concentration of quercetin within a very wide range of 1.0 × 10−10 to 1.0 × 10−3 mol L−1 was obtained, with a very low limit of detection of 3.3 × 10−11 mol L−1. To prove the performance of the method, the reproducibility was evaluated and the RSD values were lower than 5.3% and 5.1% for the intra-day and inter-day measurements, respectively. The method was applied to the sensitive determination of quercetin in human plasma droplets with recovery rates of 92.6 to 101.7%. Graphical abstract

中文翻译：

金纳米颗粒-石墨烯量子点纳米酶用于等离子体液滴中槲皮素的广泛和灵敏的电化学测定

开发了一种金纳米颗粒/石墨烯量子点 (AuNP/GQD) 纳米酶修饰的丝网印刷碳电极 (SPCE)，用于通过方波伏安法快速和超灵敏地测定槲皮素。纳米传感装置被插入到小型化设备中。在最佳实验条件下，氧化峰电流与槲皮素浓度在1.0×10-10~1.0×10-3 mol·L-1的很宽范围内具有良好的线性关系，检出限极低3.3 × 10−11 mol L−1。为了证明该方法的性能，对重现性进行了评估，日内和日间测量的 RSD 值分别低于 5.3% 和 5.1%。该方法用于人血浆液滴中槲皮素的灵敏测定，回收率为92.6%～101.7%。

更新日期：2020-10-16

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