Similar to other immune-mediated diseases, IgG4-related disease (IgG4-RD) is the disease that develops in genetically susceptible individuals exposed to external or endogenous antigens. In the present study, it was confirmed that MAG (myelin-associated glycoprotein) antibodies (IgG, IgG4, and IgM) were detected by immunofluorescence (IFA) in serum of the patients with IgG4-RD. In vivo, the levels of prolactin and Th2 cytokines in CGRP^+/− rats were higher than those in wild-type. Our findings indicate that the presence of CGRP-deficiency-mediated MAG antibodies is a probable molecular basis for the initial events which were triggered in IgG4-RD immune responses via prolactin upregulation.

与其他免疫介导的疾病类似，IgG4 相关疾病 (IgG4-RD) 是在暴露于外部或内源性抗原的遗传易感个体中发生的疾病。在本研究中，通过免疫荧光（IFA）检测证实了 IgG4-RD 患者血清中存在 MAG（髓鞘相关糖蛋白）抗体（IgG、IgG4 和 IgM）。在体内，CGRP ^+/-大鼠的催乳素和 Th2 细胞因子水平高于野生型。我们的研究结果表明，CGRP 缺陷介导的 MAG 抗体的存在是通过催乳素上调在 IgG4-RD 免疫反应中触发的初始事件的可能分子基础。