The rise of continuous flow biocatalysis – fundamentals, very recent developments and future perspectives,Reaction Chemistry & Engineering

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The rise of continuous flow biocatalysis – fundamentals, very recent developments and future perspectives
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2020-10-15 , DOI: 10.1039/d0re00335b
Piera De Santis _{1,

2,

3,

4,

5} , Lars-Erik Meyer _{1,

2,

3,

4,

5} , Selin Kara _{1,

2,

3,

4,

5}

Affiliation

Biocatalysis community has witnessed a drastic increase in the number of studies for the use of enzymes in continuously operated flow reactors. This significant interest arose from the possibility of combining the strengths of the two worlds: enhanced mass transfer and resource efficient synthesis achieved in flow chemistry at micro-scales and excellent selectivities obtained in biocatalysis. Within this review, we present very recent (from 2018 to September 2020) developments in the field of biocatalysis in continuously operated systems. Briefly, we describe the fundamentals of continuously operated reactors with a special focus on enzyme-catalyzed reactions. We devoted special attention on future perspectives in this key emerging technological area ranging from process analytical technologies to digitalization.

中文翻译：

连续流生物催化的兴起-基本原理，最新进展和未来展望

生物催化界已经看到在连续运行的流动反应器中使用酶的研究数量急剧增加。这种巨大的兴趣来自于将两个世界的优点结合在一起的可能性：在微观规模的流化学中实现了更高的传质和资源有效的合成，以及在生物催化中获得了极好的选择性。在这篇综述中，我们介绍了连续运行系统中生物催化领域的最新进展（从2018年到2020年9月）。简要地，我们描述了连续运行的反应器的基本原理，特别侧重于酶催化反应。从过程分析技术到数字化，我们在这个关键的新兴技术领域对未来的前景给予了特别的关注。

更新日期：2020-11-03

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